Abstract：Objective：To observe the clinical effect of Dahuang Zhechong Pills combined with western medicine for acute cerebral infarction of blood stasis obstructing the collaterals type and its effect on the levels of blood lipid and inflammatory factors in patients. Methods：A total of 88 cases of patients with acute cerebral infarction of blood stasis obstructing the collaterals type were randomly divided into the treatment group and the control group， with 44 cases in each group. The control group was treated with routine western medicine，and the treatment group was additionally treated with Dahuang Zhechong Pills based on the treatment of the control group. The clinical effects in the two groups were compared，and the levels of blood lipid， inflammatory factors and National Institutes of Health Stroke Scale(NIHSS) scores before and after treatment were compared between the two groups. Results： Before treatment， there was no significant difference being found in the comparison of NIHSS scores between the two groups(P＞0.05). After treatment，NIHSS scores in the two groups were decreased(P＜0.05)，and the score in the treatment group was lower than that in the control group(P＜0.05). The total effective rate was 97.73% in the treatment group， higher than that of 88.64% in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of total cholesterol(TC)，triglyceride(TG)， low- density lipoprotein cholesterol(LDL- C) and high- density lipoprotein cholesterol(HDL- C) in serum between the two groups(P＞0.05). After treatment，the levels of TC，TG and LDL-C in serum in the two groups were decreased(P＜0.05)，and the levels of HDL-C were increased(P＜0.05). The levels of TC，TG and LDL-C in serum in the treatment group were lower(P＜0.05)，and the level of HDL-C was higher than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of C- reactive protein(CRP)， interleukin- 6(IL- 6)， interleukin- 8(IL- 8) and tumor necrosis factor-A(TNF-a) in serum between the two groups(P＞0.05). After treatment，the levels of CPR，IL-6，IL-8 and TNF-α in serum in the two groups were decreased(P＜0.05)，and the above levels in the treatment group were lower than those in the control group(P＜0.05). Conclusion： The therapy of Dahuang Zhechong Pills combined with western medicine for acute cerebral infarction of blood stasis obstructing the collaterals type has a good curative effect，and can effectively reduce the clinical symptoms of patients， enhance the cure rate and improve the indexes of biochemical， which worthy of clinical promotion and research.