Abstract: Objective: To observe the curative effect of Qingfei Liyan Prescription combined with routine western medicine for suppurative tonsillitis in children, and its effect on inflammatory responses and immune function. Methods:A total of 80 cases of children with suppurative tonsillitis were selected as the study subjects and divided into the observation group and the control group according to the random number table method, with 40 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Qingfei Liyan Prescription based on the treatment of the control group. The clinical effects in the two groups were evaluated. The inflammatory factors levels and immune function before and after treatment and the symptom relief time in the two groups were compared. Results: The total clinical effective rate was 97.50% in the observation group, better than that of 82.50% in the control group(P<0.05). The disappearance time of purulent secretion,the relief time of pharyngeal pain and the time for temperature to return to normal in the observation group were earlier than those in the control group(P<0.05). After treatment, the levels of interleukin- 4(IL- 4) and interleukin-6(IL-6) in serum in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group(P<0.05);the levels of CD3+,CD4+ and CD4 +/CD8 + in the two groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group(P<0.05);the CD8+ levels in the two groups were lower than those before treatment,and the level in the observation group was lower than that in the control group (P<0.05). Conclusion:Qingfei Liyan Prescription combined with routine western medicine has a significant curative effect in treating suppurative tonsillitis in children, and can promote the relief of symptoms, reduce inflammatory responses and improve the immunity in the body.