Abstract：Objective：To observe the clinical effect of Qufeng Chushi Tongmai Prescription combined with western medicine for rheumatoid arthritis(RA). Methods： A total of 64 cases of RA patients were selected and divided into the observation group and the control group according to the random number table method， with 32 cases in each group. The control group was treated with western medicine， and the observation group was additionally treated with Qufeng Chushi Tongmai Prescription based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects in the two groups were compared. Before and after treatment， the changes in Disease Activity Score in 28 Joints (DAS28) scores and levels of erythrocyte sedimentation rate(ESR)， C- reactive protein(CRP) and tumor necrosis factor-α(TNF-α) were compared between the two groups. Results：The total clinical effective rate was 93.75% in the observation group and 78.13% in the control group，the difference being significant(P＜ 0.05). From 4 to 12 weeks after treatment，CRP in the two groups were decreased when compared with those before treatment(P＜0.05)；from 8 to 12 weeks after treatment，ESR and DAS28 scores in the two groups were decreased when compared with those before treatment(P＜0.05). After 8 weeks of treatment，the levels of ESR and CRP in the observation group were lower than those in the control group (P＜0.05). After 12 weeks of treatment，the DAS28 score in the observation group was lower than that in the control group(P＜0.05). After treatment， the TNF- α levels in the two groups were decreased when compared with those before treatment(P＜0.05)， there being no significance in the difference(P＞0.05). Conclusion：Qufeng Chushi Tongmai Prescription combined with western medicine can effectively relieve clinical symptoms of RA patients，reduce disease activity and improve inflammatory indexes.