Abstract： Objective： To observe the clinical effect of Wenshen Jianpi Lishui Prescription combined with Valsartan Capsules in treating chronic glomerulonephritis(CG) of spleen- kidney qi deficiency type. Methods：A total of 443 cases of CG patients were selected as the study objectives and divided into the observation group and the control group according to the random number table method， with 222 and 221 cases in each group respectively. The control group was treated with Valsartan Capsules， and the observation group was treated with Wenshen Jianpi Lishui Prescription combined with Valsartan Capsules. Both groups were treated for two months. Clinical effects and the incidences of adverse reactions in the two groups were observed. Changes in Chinese medicine syndrome scores， the kidney function indexes [blood urea nitrogen(BUN)， serum creatinine(SCr)， urine protein ratio(Upr)]， and inflammatory factors [interleukin- 6(IL- 6) ， C- reactive protein(CRP) ， tumor necrosis factor- α (TNF- α )] before and after treatment in the two groups were compared. Results：The total clinical effective rate was 95.05% in the observation group and 90.05% in the control group， the difference being significant(P＜0.05). After treatment， traditional Chinese medicine(TCM) syndrome scores of vertigo and dizzy vision， turbid urine， and bloody urine in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above three TCM syndrome scores in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of BUN， SCr， and URP in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of CRP，IL-6，and TNF-α in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the observation group were lower than those in the control group (P＜0.05). After treatment， the incidence of adverse reactions was 4.95% in the observation group and 7.24% in the control group， there being no significance in the difference(P＞0.05). Conclusion： In the treatment of CG， Wenshen Jianpi Lishui Prescription combined with Valsartan Capsules can enhance clinical effect， relieve clinical symptoms，reduce inflammatory responses，and improve the kidney function.