Abstract：Objective：To study the intervention effect of Chinese medicine health management on type 2 diabetes mellitus of yin- deficiency constitution. Methods： The target residents of Chinese medicine health management in Haizhu District， Guangzhou in 2017 and 2018 were selected according to the Chinese Medicine Health Management Service Record Form for the Elderly ， and 600 cases with type 2 diabetes mellitus of yin- deficiency constitution were selected. They were randomly divided into the intervention group and the control group， with 300 cases in each group. The control group was given management of chronic disease， and the intervention group was given Chinese medicine health management. The changes of Chinese medicine constitution，fasting blood glucose and body mass index before intervention， 12 months after intervention and 24 months after intervention were compared between the two groups，and the safety in the two groups was detected during treatment. Results：After 24 months of intervention，among 300 residents with diabetes mellitus of yin-deficiency constitution in the intervention group，88 cases turned to balanced constitution；121 cases tended to turn to yin-deficiency constitution， and 91 cases remained yin- deficiency constitution. Among 300 residents with diabetes mellitus of yin- deficiency constitution in the control group， 12 cases turned to balanced constitution； 39 cases tended to turn to yin- deficiency constitution， and 249 cases remained yin- deficiency constitution. There was significant difference in the comparison of the turn in constitution(P＜0.01). After 12 and 24 months of intervention， the levels of body mass index and fasting blood glucose in the two groups were decreased when compared with those before intervention， the difference being significant (P＜0.05). After 12 and 24 months of intervention，the levels of body mass index and fasting blood glucose in the intervention group were lower than those in the control group at the same period， the difference being significant(P＜0.05). During the study，the levels of blood routine and liver and kidney functions in the two groups were monitored，and there were no obvious abnormal results leading to the termination of the study. Conclusion： The intervention effect of Chinese medicine health management on type 2 diabetes mellitus of yin- deficiency constitution is significant. The related service items in the Chinese medicine health management can effectively improve the quality of life and prognosis of patients with type 2 diabetes mellitus of yin-deficiency constitution and guide them to develop a healthier lifestyle.