Abstract： Objective： To observe the curative effect of the Qufeng Huatan Zhuyu method combined with western medicine on dizziness after stroke and its effect on hemodynamic parameters， calcitonin gene- related peptide(CGRP) of peripheral blood and soluble CD40 ligand(sCD40L). Methods： A total of 105 patients with dizziness after stroke were selected as the research objects and divided into the western medicine group and the Chinese and western medicine group according to different treatment methods， with 52 and 53 cases in each group respectively. Both groups were treated with routine treatment. The western medicine group was additionally treated with western medicine based on the routine treatment， and the Chinese and western medicine group was additionally treated with the Qufeng Huatan Zhuyu method based on the treatment of the western medicine group. Before and after treatment，the changes of traditional Chinese medicine(TCM syndrome scores， hemodynamic parameters， including the peak systolic velocity(Vs)， end diastolic velocity(Vd) and mean velocity(Vm) of left vertebral artery(LVA)， right vertebral artery(RVA) and basilar artery(BA)， and levels of serum related factors， including CGRP， sCD40L， milk fat globule- epidermal growth- factor VIII(MFG- E8) and endothelin- 1(ET- 1)， were compared between the two groups. The incidence of adverse reactions in the two groups was observed. Results：After two months of treatment，the TCM syndrome scores of dizziness，headache，tinnitus and chest oppression in the two groups were decreased when compared with those before treatment(P＜ 0.05)，and the above four scores in the Chinese and western medicine group were lower than those in the western medicine group(P＜0.05). After two months of treatment，the levels of RVA-Vs，RVA-Vd，RVAVm， LVA-Vs，LVA-Vd，LVA-Vm，BA-Vs，BA-Vd and BA-Vm in the two groups were increased when compared with those before treatment(P＜0.05)， and the above nine hemodynamic parameters in the Chinese and western medicine group were higher than those in the western medicine group(P＜0.05). After two months of treatment，the levels of ET- 1，MFG- E8 and sCD40L in the two groups were decreased when compared with those before treatment，and the levels of CGRP were increased，differences being significant(P＜0.05)；the levels of ET-1，MFG-E8 and sCD40L in the Chinese and western medicine group were lower than those in the western medicine group，and the level of CGRP was higher than that in the western medicine group， differences being significant(P＜0.05). The incidence of adverse reactions was 3.77% in the Chinese and western medicine group and 7.69% in the western medicine group，there being no significance in the difference(P＞0.05). Conclusion： The therapy of the Qufeng Huatan Zhuyu method combined with western medicine for dizziness after stroke can enhance the clinical effect， regulate the levels of serum related factors，improve the Chinese medicine syndrome scores，and regulate and control the hemodynamic parameters，with high safety.