盐酸美金刚联合复方海蛇胶囊治疗阿尔茨海默病临床研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R749.1+6

基金项目:


Clinical Study on Memantine Hydrochloride Combined with Compound Haishe Capsules for Alzheimer Disease
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:观察盐酸美金刚联合复方海蛇胶囊治疗阿尔茨海默病的临床疗效。方法:选取90 例阿尔茨 海默病患者,按随机数字法分为对照组和治疗组各45 例。对照组应用盐酸美金刚治疗,治疗组应用盐酸美金 刚联合复方海蛇胶囊治疗。2 组疗程均为3 个月,治疗后观察比较2 组临床疗效,以及治疗前后简易智力状态 量表(MMSE) 评分、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]水 平、神经损伤指标[血清S-100 钙结合蛋白B (S-100B)、神经元特异性烯醇化酶(NSE) 及髓鞘碱性蛋 白(MBP)]水平。结果:治疗组总有效率为95.56%,对照组为73.33%,2 组比较,差异有统计学意义(P< 0.05)。治疗后,2 组血清炎性因子IL-6、IL-8、TNF-α水平均较治疗前降低(P<0.05),且治疗组上述炎性因 子水平均低于对照组(P<0.05)。治疗后,2 组MMSE 量表中注意力和计算力、定向力、记忆力、语言能力、 视空间和执行功能评分均较治疗前提高(P<0.05),且治疗组上述各项评分均高于对照组(P<0.05)。治疗 后,2 组神经损伤指标S-100B、NSE、MBP 水平均较治疗前降低(P<0.05),且治疗组S-100B、NSE、MBP 水平均低于对照组(P<0.05)。结论:盐酸美金刚联合复方海蛇胶囊治疗阿尔茨海默病疗效显著,可降低炎症 因子及神经损伤指标水平,改善患者智力和痴呆行为。

    Abstract:

    Abstract: Objective: To observe the clinical effect of the therapy of memantine hydrochloride combined with compound Haishe Capsules on Alzheimer disease. Methods: A total of 90 patients with Alzheimer disease were selected and divided into the control group and the treatment group according to the random number table method, with 45 cases in each group. The control group was treated with memantine hydrochloride,and the treatment group was treated with memantine hydrochloride combined with compound Haishe Capsules. Both groups were treated for three months. The clinical effects,scores of Mini- Mental State Examination(MMSE) and levels of inflammatory factors, including tumor necrosis factor- α(TNF- α), interleukin- 6(IL- 6) and interleukin- 8(IL- 8), and indexes of nerve injury, including serum S-100 calcium-binding protein B(S-100B),neuron-specific enolase(NSE) and myelin basic protein (MBP),were observed and compared before and after treatment between the two groups. Results:The total effective rate was 95.56% in the treatment group and 73.33% in the control group, the difference being significant(P<0.05). After treatment,the levels of serum inflammatory factors,including IL-6,IL-8 and TNF- α, in the two groups were decreased when compared with those before treatment(P<0.05), and the above three levels in the treatment group were lower than those in the control group(P<0.05). After treatment, the scores of attention and calculation capacities, orientation, memory, language skills, visuospatial abilities and executive function in the MMSE scale in the two groups were increased when compared with those before treatment(P<0.05),and the above scores in the treatment group were higher than those in the control group(P<0.05). After treatment,the levels of indexes of nerve injury,including S- 100B, NSE and MBP were decreased when compared with those before treatment(P<0.05), and the above three levels in the treatment group were lower than those in the control group(P<0.05). Conclusion: The therapy of memantine hydrochloride combined with compound Haishe Capsules has a good curative effect on Alzheimer disease, which can reduce the levels of inflammatory factors and indexes of nerve injury and improve the intelligence and dementia behaviors of patients.

    参考文献
    相似文献
    引证文献
引用本文

方郁丹,洪小琴,周会霞.盐酸美金刚联合复方海蛇胶囊治疗阿尔茨海默病临床研究[J].新中医,2022,54(24):68-72

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2023-01-01
  • 出版日期: