Abstract： Objective： To observe the clinical effect of Wenyang Buxin Tang for chronic cardiac insufficiency of heart- kidney yang deficiency type and its effect on N- terminal pro B- type natriuretic peptide(NT-proBNP) in plasma，left ventricular ejection fraction(LVEF)，exercise endurance and mechanism. Methods：A total of 80 cases of patients with chronic cardiac insufficiency of heart-kidney yang deficiency type were divided into the control group and the observation group according to the random number table method，with 40 cases in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with Wenyang Buxin Tang based on the treatment of the control group. The clinical effects in the two groups were compared. Before and after treatment， the cardiopulmonary function including anaerobic threshold(AT)，maximal oxygen consumption(VO2 max)，oxygen pulse(O2 pulse)，maximal exercise time and LVEF，the distance in six-minute walk test，Minnesota Living With Heart Failure Questionnaire(MLWHFQ)， NT- proBNP in plasma， and the levels of inflammatory factors including high- sensitivity C- reactive protein(hs- CRP)， tumor necrosis factor- α(TNF- α) and interleukin- 18(IL- 18) in the two groups were compared. Results： The total effective rate of cardiac function was 80.0% in the observation group，higher than that of 67.5% in the control group(P＜0.05)；the total effective rate of Chinese medicine syndromes was 82.5% in the observation group，higher than that of 62.5% in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of AT，VO2 max，O2 pulse，maximal exercise time and LVEF between the two groups(P＞ 0.05). After treatment，the AT，VO2 max，O2 pulse，maximal exercise time and LVEF in the observation group were increased(P＜0.05)， and the indexes in the observation group were higher than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the six-minute walk test，NT-proBNP levels and MLWHFQ scores between the two groups (P＞0.05). After treatment， the distance in six- minute walk test in the two groups was prolonged(P＜ 0.05)，and NT-proBNP levels and MLWHFQ scores were decreased(P＜0.05)；the distance in six-minute walk test in the observation group was longer than that in the control group(P＜0.05)，and the NT-proBNP level and MLWHFQ score were lower(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of hs-CRP，TNF-α and IL-18 between the two groups(P＞0.05). After treatment， the levels of hs- CRP， TNF- α and IL- 18 in the two groups were decreased(P＜0.05)， and the levels in the observation group were lower than those in the control group(P＜0.05). Conclusion： Wenyang Buxin Tang can effectively improve the clinical effects，exercise endurance and quality of life of patients with chronic cardiac insufficiency of heart- kidney yang deficiency type， reduce NT- proBNP levels，and enhance cardiopulmonary function，which may be related to its ability to reduce the expression levels of inflammatory factors including hs-CRP，TNF-α and IL-18.