龙胆泻肝汤加味联合艾司唑仑治疗肝郁化火型失眠症临床研究
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R256.23

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Clinical Study on Modified Longdan Xiegan Tang Combined with Estazolam Tablets for Insomnia of Depressed Liver Qi Transforming into Fire Type
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    摘要:

    目的:观察龙胆泻肝汤加味联合艾司唑仑治疗肝郁化火型失眠症的临床疗效。方法:选取92 例肝 郁化火型失眠症患者,按随机数字表法分为对照组和研究组各46 例。对照组应用艾司唑仑片治疗,研究组在 对照组的基础上加用龙胆泻肝汤治疗。治疗4 周后,观察比较2 组临床疗效、匹兹堡睡眠质量指数(PSQI) 评分及中医证候积分。结果:研究组总有效率为95.7%,对照组为80.4%,2 组比较,差异有统计学意义(P< 0.05)。治疗前,2 组中医证候积分比较,差异无统计学意义(P>0.05);治疗2、4 周后,2 组中医证候积分 均较治疗前显著降低(P<0.05),且研究组相同时间点的证候积分均低于对照组(P<0.05)。治疗前,2 组日 间功能、催眠时间、睡眠障碍、睡眠效率、睡眠时间、入睡时间、睡眠质量等PSQI 量表各项评分比较,差异 无统计学意义(P>0.05);治疗后,2 组上述各项评分均较治疗前显著降低(P<0.05),且研究组各项评分均 低于对照组(P<0.05)。结论:龙胆泻肝汤加味联合艾司唑仑片治疗肝郁化火型失眠症能提高临床疗效,改善 患者中医证候及睡眠质量,疗效优于单纯西药治疗。

    Abstract:

    Abstract: Objective: To observe the clinical effect of modified Longdan Xiegan Tang combined with Estazolam Tablets for insomnia of depressed liver qi transforming into fire type. Methods : A total of 92 cases of patients with insomnia of depressed liver qi transforming into fire type were selected and divided into the control group and the study group according to the random number table method, with 46 cases in each group. The control group was treated with Estazolam Tablets,and the study group was additionally treated with Longdan Xiegan Tang based on the treatment of the control group. After four weeks of treatment, the clinical effects, Pittsburgh Sleep Quality Index(PSQI) scores and traditional Chinese medicine(TCM) syndrome scores in the two groups were observed and compared. Results: The total effective rate was 95.7% in the study group and 80.4% in the control group,the difference being significant (P<0.05). Before treatment, there was no significant difference being found in the comparison of TCM syndrome scores between the two groups(P>0.05). After two and four weeks of treatment,TCM syndrome scores in the two groups were significantly decreased when compared with those before treatment(P< 0.05),and the syndrome score in the study group was lower than that in the control group at the same time point(P<0.05). Before treatment,there was no significant difference being found in the comparison of the scores of PSQI including daytime function,hypnotics,sleep disorder,sleep efficiency,sleep time,time for falling asleep and sleep quality between the two groups(P>0.05);after treatment,the above scores in the two groups were significantly decreased when compared with those before treatment(P<0.05), and the scores in the study group were lower than those in the control group(P<0.05). Conclusion:The therapy of modified Longdan Xiegan Tang combined with Estazolam Tablets for insomnia of depressed liver qi transforming into fire type can enhance the clinical effect,and improve TCM syndrome scores and sleep quality,with a better curative effect than that of simple western medicine.

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刘铭芳,任永富.龙胆泻肝汤加味联合艾司唑仑治疗肝郁化火型失眠症临床研究[J].新中医,2022,54(24):46-49

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  • 在线发布日期: 2023-01-01
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