Abstract： In the long- term clinical practice， Prof. LYU Renhe， a master of Chinese medicine， concluded “six ways of diagnosis and treatment”method to treat idiopathic membranous nephropathy. In view of the core pathogenesis of this disease——healthy qi depletion and damp-heat toxin stasis caused by pathogenic qi blocking off kidney collaterals，he treated it with the main principle of reinforcing healthy qi and dispelling pathogen while dredging collaterals and boosting the kidney， and paid much attention on syndrome differentiation according to the pathological stages. He used the unique methods of "determining the syndrome type by deficiency in origin” and “determining the syndrome by excess in superficiality”. When basing on the deficiency of qi and blood and the damage of qi and yin， he flexibly adjusted the medication according to the changes of pathogenic excess，such as internal heat，blood stasis，dampness obstruction， water retention， etc. In addition， he paid attention to specific symptoms and symptomatic differentiation，and emphasized on the solution of the secondary syndromes caused by western medicine like Corticosteroids. In many years of clinical observation， his treatment achieved a good effect. The application of “six ways of diagnosis and treatment”method in treating idiopathic membranous nephropathy was analyzed in detail with one medical case.