Abstract：Objective：To observe the curative effect of directional transdermal therapy combined with rehabilitation training of bilateral upper limbs on upper limb motor dysfunction in convalescence of stroke. Methods： A total of 100 cases of patients with bilateral upper limbs on upper limb motor dysfunction in convalescence of stroke were selected and divided into Group A and Group B according to the random number table method，with 50 cases in each group. Both groups were given basic treatment；Group A was additionally given rehabilitation training of bilateral upper limbs，and Group B was additionally treated with directional transdermal therapy based on the treatment of Group A. Both groups were treated for two months. The EMG values of upper limb surface muscles and the scores of Fugl Meyer Motor Function Assessment Scale(FMA) ， Action Research Arm Test(ARAT) ， Activity of Daily Living Scale(ADL) and 36- Item Short Form Survey(SF- 36) before and after treatment were compared between the two groups. Results：After treatment，the EMG values of trapezius，anterior bundle of deltoid，and biceps brachii in the two groups were increased when compared with those before treatment(P＜0.05)， and the three values in Group B were higher than those in Group A(P＜0.05). After treatment，scores of FMA，ARAT， ADL and SF-36 in the two groups were increased when compared with those before treatment(P＜0.05)， and the above scores in Group B were higher than those in Group A(P＜0.05). Conclusion：For patients in convalescence of stroke， directional transdermal therapy combined with rehabilitation training of bilateral upper limbs can improve their motor function of upper limbs，ability of daily living and quality of life.