Abstract：Objective：To observe the clinical effect of central-square needling technique of warmingneedle moxibustion on L3 transverse process syndrome. Methods：A total of 80 patients with L3 transverse process syndrome were selected and divided into the control group and the observation group according to the random number table method， with 40 cases in each group. The control group was treated with conventional acupuncture，and the observation group was treated with central-square needling technique of warming- needle moxibustion. The clinical effects， scores of clinical signs， scores of McGill Pain Questionnaire and the changes of the thickest muscle layer of the affected side before and after treatment were observed in the two groups. Results： After treatment， the total effective rate was 97.5% in the observation group and 82.5% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference in the scores of McGill Pain Questionnaire and clinical signs between the two groups(P＞0.05)； after treatment， the scores of McGill Pain Questionnaire and clinical signs in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above two scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference in the muscle thickness of affected side between the two groups(P＞0.05)；after treatment，the muscle thickness of the affected side in both groups was decreased when compared with that before treatment(P＜0.05)，and the muscle thickness of the affected side in the observation group was smaller than that in the control group(P＜0.05). Conclusion： Central- square needling technique of warming-needle moxibustion has a significant effect on improving the clinical signs of patients with L3 transverse process syndrome，which can reduce pain and local soft tissue edema and has a better curative effect than conventional acupuncture.