Abstract：Objective：To observe the clinical effect of Xiao'er Changweikang Granules combined with Mosapride Tablets for infantile functional dyspepsia(FD). Methods： FD children of spleen deficiency and liver hyperactivity type involved in the study were randomly divided into the observation group and the control group，with 43 cases in each group. Both groups were treated with routine modern medicine and Mosapride Tablets， and the observation group was additionally treated with Xiao'er Changweikang Granules based on the treatment of the control group. Both groups were treated for four weeks. Before and after treatment，the levels of gastrin(GAS)，motilin(MTL)，ghrelin，tumor necrosis factor-α(TNF-α)， interleukin- 6(IL- 6) and interleukin- 10(IL- 10) in serum were detected. The gastric emptying rates were counted. During treatment，the incidence of adverse reactions in children in the two groups were observed. The clinical effects in the two groups were compared. Results： After four- week treatment， the total effective rate of clinical effect in the observation group was higher than that in the control group， there being no significance in the difference(P＞0.05). The levels of MTL， GAS and ghrelin， and the gastric emptying rates in the two groups were higher than those before treatment， differences being significant (P＜0.01). The levels of MTL， GAS and ghrelin， and the gastric emptying rate in the observation group were higher than those in the control group， differences being significant(P＜0.01). The levels of TNF- α and IL- 6 in the two groups were lower and the IL- 10 levels were higher than those before treatment， differences being significant(P＜0.01). The levels of TNF-α and IL-6 in serum in the observation group were lower and the IL- 10 level was higher than those in the control group， differences being significant(P＜ 0.01). The four syndrome scores such as fullness and food less poor appetite in the two groups were lower than those before treatment， differences being significant(P＜0.01)； the four syndrome scores in the observation group were lower than those in the control group， differences being significant(P＜0.01). Conclusion： Xiao'er Changweikang Granules combined with Mosapride Tablets can effectively treat infantile FD，which can improve symptoms such as fullness in the stomach and less food intake with poor appetite，increase gastric motility and promote gastric emptying with good safety.