Abstract：Objective：To observe the clinical effect of Fupi Shugan Tang combined with live combined bifidobacterium， lactobacillus and enterococcus capsules for chronic diarrhea after surgery of gallbladder polyps with liver constraint overwhelming spleen. Methods： A total of 80 cases of patients with postoperative chronic diarrhea and syndrome of the liver constraint overwhelming the spleen were selected and divided into the control group and the observation group according to the random number table method，with 40 cases in each group. The control group was treated with Live combined bifidobacterium， lactobacillus and enterococcus capsules， and the observation group was additionally treated with Fupi Shugan Tang based on the treatment of the control group. Both groups were treated for eight weeks. Clinical effects， stool frequency， stool characteristics， nutritional status， intestinal flora， intestinal mucosal damage degree and the incidence of adverse reactions were compared between the two groups. Results：The total effective rate was 95.00% in the observation group，higher than that of 77.50% in the control group(P＜0.05). After treatment，scores of stool characteristics in the two groups were decreased when compared with those before treatment(P＜0.05)，and the stool frequency was decreased(P＜0.05)； the score of stool characteristics in the observation group was lower than that in the control group(P＜ 0.05)，and the stool frequency was less(P＜0.05). After treatment，hemoglobin(Hb) levels and Body Mass Index(BMI) in the two groups were increased when compared with those before treatment(P＜0.05)，and scores of Patient- Generated Subjective Global Assessment(PG- SGA) were decreased(P＜0.05)；Hb level and BMI in the observation group were higher than those in the control group(P＜0.05)，and the PG-SGA score was lower(P＜0.05). After treatment，escherichia coli levels in the two groups were decreased when compared with those before treatment(P＜0.05)， and levels of bifidobacterium and lactobacillus were increased(P＜0.05)；escherichia coli level in the observation group was lower than that in the control group (P＜0.05)，and levels of bifidobacterium and lactobacillus were higher(P＜0.05). After treatment，scores of intestinal mucosal lesion in the two groups were decreased when compared with those before treatment (P＜0.05)，and the score in the observation group was lower than that in the control group(P＜0.05). The incidence of adverse reactions was 10.00% in the observation group and 5.00% in the control group，there being no significance in the difference(P＞0.05). Conclusion： Fupi Shugan Tang combined with live combined bifidobacterium，lactobacillus and enterococcus capsules have a good curative effect in treating postoperative chronic diarrhea in patients with gallbladder polyps and liver constraint overwhelming the spleen syndrome. It can improve the nutritional status of patients， regulate intestinal flora， and reduce intestinal mucosal damage，with high safety.