Abstract： Objective： To observe the clinical effect of compound Biejia Ruangan Tablets for patients with liver fibrosis induced by chronic hepatitis B. Methods：A total of 112 cases of patients with liver fibrosis induced by chronic hepatitis B were divided into the treatment group and the control group according to the random number table method，with 56 cases in each group. The control group was treated with Tenofovir Disoproxil Fumarate Tablets， and the treatment group was additionally treated with compound Biejia Ruangan Tablets based on the treatment of the control group. Both groups were treated for 12 months. The changes in levels of liver function indexes including aspartate aminotransferase(AST)， alanine aminotransferase(ALT)， total bilirubin(TBil) and γ- glutamate acyltransferase(GGT)， and liver fibrosis indexes including hyaluronic acid(HA)，type Ⅲ procollagen(PCⅢ)，type Ⅳ collagen(Ⅳ-C) and laminin(LN)， as well as clinical effects in the two groups were compared. Results：The total effective rate was 92.86% in the treatment group， significantly higher than that of 76.79% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of AST，ALT，GGT and TBil in serum between the two groups(P＞0.05). After treatment，the levels of AST， ALT， GGT and TBil in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above indexes in the treatment group were significantly lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of HA，PCⅢ，Ⅳ- C and LN in serum between the two groups(P＞0.05). After treatment， the levels of HA， PC Ⅲ， Ⅳ- C and LN in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above liver fibrosis indexes in the treatment group were significantly lower than those in the control group(P＜0.05). Conclusion： Based on routine western medicine treatment，the additional application of compound Biejia Ruangan Tablets for liver fibrosis induced by chronic hepatitis B has a significant curative effect， which can better improve the indexes of liver function and liver fibrosis of patients.