Abstract：Objective：To observe the effect of the therapy of Liuhe Pellets in the adjuvant treatment of severe acute pancreatitis. Methods： A total of 100 patients with severe acute pancreatitis with livergallbladder dampn-heat or bowel excess and heat bind syndrome were selected and divided into the control group and the observation group according to the random number table method， with 50 cases in each group. Both groups were treated with routine basic treatment and early enteral nutrition supplemented with probiotics， and the observation group was additionally given wet compressing with Liuhe Pellets. Both groups were treated for 14 days continuously. Before and after treatment，the improvement of symptoms and the severity of disease in the two groups were evaluated by the symptom scores and Balthazar CT classification score，and the intestinal mucosal barrier function and immune function were evaluated. The clinical effects were compared between the two groups. Results： After 14 days of treatment， the total clinical effective rate was 90.00% in the observation group， higher than that of 72.00% in the control group，the difference being significant(P＜0.05). The symptom scores and Balthazar CT classification score in the two groups were decreased when compared with those before treatment(P＜0.01)，and the above two scores in the observation group were lower than those in the control group(P＜0.01). The levels of diamine oxidase and D- lactate in the two groups were decreased when compared with those before treatment(P＜0.01)，and the above two levels in the observation group were lower than those in the control group(P＜0.01). The levels of CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment， and the levels of CD8 + were decreased， differences being significant(P＜0.01)； the levels of CD4+ and CD4+/CD8+ in the observation group were higher and the level of CD8+ was lower than those in the control group， differences being significant(P＜0.01). Conclusion： The application of Liuhe pellets in the adjuvant treatment of acute pancreatitis with liver- gallbladder dampn- heat or bowel excess and heat bind syndrome is helpful to control the disease progression，improve the intestinal mucosal barrier function and immune function，and enhance the curative effect.