Abstract： Objective： To observe the clinical effect of Tongqiao Yizhi Tang combined with cognitive training for cognitive dysfunction after cerebral infarction. Methods： A total of 100 cases of patients with cognitive dysfunction after cerebral infarction were selected and divided into the control group and the observation group according to the random number table method， with 50 cases in each group. Both groups were given routine treatment；the control group was additionally given cognitive training，and the observation group was additionally treated with Tongqiao Yizhi Tang based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effects， cognitive function， neurological function， activities of daily living and neurotransmitter levels in the two groups were compared. Results： The total effective rate was 94.00% in the observation group， higher than that of 78.00% in the control group(P＜0.05). After treatment， the scores of visual space and executive ability， language function， attention and calculation function，abstraction，orientation and delayed recall as well as the total scores of Montreal Cognitive Assessment(MoCA) in the two groups were significantly higher than those before treatment(P＜0.05)；the above scores in the observation group were higher than those in the control group (P＜0.05). After treatment， the scores of National Institutes of Health Stroke Scale(NIHSS) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of Functional Independence Measure(FIM) were increased(P＜0.05)； the NIHSS score in the observation group was lower than that in the control group(P＜0.05)， and the FIM score was higher(P＜0.05). After treatment，the levels of acetylcholine(ACh) and norepinephrine(NE) in the two groups were increased when compared with those before treatment(P＜0.05)， and the levels of ACh and NE in the observation group were higher than those in the control group(P＜0.05). Conclusion： The therapy of Tongqiao Yizhi Tang combined with cognitive training for cognitive dysfunction after cerebral infarction can effectively improve the cognitive function of patients，relieve their neurologic impairment，and enhance their activities of daily living，and its action mechanism is related to the improvement of the levels of neurotransmitters.