Abstract ： Objective ： To observe the clinical effect of acupuncture combined with artificial tears for asthenopia caused by xerophthalmia. Methods：A total of 60 cases of patients with asthenopia caused by xerophthalmia were divided into the control group and the acupuncture group according to the random number table method， with 30 cases in each group. The control group was treated with Carboxymethylcellulose Sodium Lubricant Eye Drops，and the acupuncture group was additionally treated with acupuncture at periocular points based on the treatment of the control group. Both groups were treated for 10 days. The clinical effects and the incidence of adverse reactions in the two groups were observed. The changes in symptom scores，breakup time of tear film(BUT)，corneal fluorescein staining(CFS) score， Schirmer I test(SIT) and visual persistence(BVP) before treatment， on the first day and tenth day of treatment in the two groups were compared. Results： On the first day and tenth day of treatment， the symptom scores in the two groups were decreased when compared with those before treatment，and the difference was statistically significant in the acupuncture group when compared with those before treatment (P＜0.05). On the first day and tenth day of treatment，the symptom scores in the acupuncture group were lower than those in the control group at the same time period(P＜0.05). On the first day and tenth day of treatment， BUT values in the two groups were increased when compared with those before treatment， and the difference was statistically significant in the acupuncture group when compared with those before treatment(P＜0.05). On the first day and tenth day of treatment，BUT values in the acupuncture group were higher than those in the control group at the same time period(P＜0.05). On the first day and tenth day of treatment，the SIT values in the two groups were increased when compared with those before treatment (P＜0.05)，and the SIT values in the acupuncture group were higher than those in the control group at the same time period(P＜0.05). On the first day and tenth day of treatment，the CFS scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the CFS scores in the acupuncture group were lower than those in the control group at the same time period； there was significant difference being found in the comparison of the CFS scores between the two groups on the tenth day of treatment(P＜0.05). On the first day and tenth day of treatment，the BVP values in the two groups were increased when compared with those before treatment(P＜0.05)， and the BVP values in the acupuncture group were higher than those in the control group at the same time period(P＜0.05). The total clinical effective rate was 60.0% in the control group and 86.7% in the acupuncture group，the difference being significant(P＜0.05). During treatment， there was no adverse reaction in the two groups. Conclusion： The therapy of acupuncture combined with artificial tears for asthenopia caused by xerophthalmia has a good clinical effect， which can improve dry eye symptoms， relieve asthenopia and promote tear secretion.