Abstract：Objective：To observe the clinical effect of Wenjing Sanhan Huoxue Prescription combined with Funv Yangxue Pills and Hongjin Xiaojie Capsules for hysteromyoma with cold accumlation causing blood stasis syndrome. Methods： A total of 113 cases of patients with hysteromyoma with cold accumulation causing blood stasis syndrome were selected and divided into the study group and the control group according to the random number table method，with 57 and 56 cases in each group respectively. The control group was treated with Funv Yangxue Pills and Hongjin Xiaojie Capsules，and the study group was additionally given oral administration of Wenjing Sanhan Huoxue Prescription based on the treatment of the control group. The clinical effects in the two groups were evaluated. Before and after treatment， the changes in sex hormones levels， Chinese medicine syndrome scores， and levels of hemodynamics and hemorrheology indexes were compared between the two groups. Before and after treatment，the changes in uterine fibroid volume， uterine volume and menstrual volume were detected. Results： The total effective rate was 92.98% in the study group， higher than that of 80.36% in the control group(P＜0.05). After treatment， the levels of follicle stimulating hormone(FSH)， luteinizing hormone(LH)， estrogen(E2) and progesterone(P) in the two groups were decreased when compared with those before treatment(P＜ 0.05)，and the levels of FSH，LH，E2 and P in the study group were lower than those in the control group (P＜0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and the Chinese medicine syndrome scores in the study group were lower than those in the control group(P＜0.05). After treatment，pulsatility indexes(PI)， resistance index(RI) and hematocrit(Hct) in the two groups were increased when compared with those before treatment，and the fibrinogen(FIB) levels were decreased(P＜0.05)；the levels of PI，RI and Hct in the study group were higher than those in the control group，and the FIB level was lower(P＜0.05). After treatment，the uterine volume，fibroid volume and menstrual volume in the two groups were decreased when compared with those before treatment(P＜0.05)， and the uterine volume， fibroid volume and menstrual volume in the study group were lower than those in the control group(P＜0.05). Conclusion： Wenjing Sanhan Huoxue Prescription combined with Funv Yangxue Pills and Hongjin Xiaojie Capsules for hysteromyoma with cold accumulation causing blood stasis syndrome can effectively improve clinical effects， clinical symptoms and hemodynamics and hemorrheology indexes， regulate the expressions of sex hormones in serum and reduce the fibroid volume.