Abstract：Objective：To observe the clinical effect of Shugan Jieyu Prescription for erectile dysfunction (ED) of liver depression and qi stagnation type. Methods：A total of 90 cases of ED patients were selected and divided into the trial group and the control group according to the random number table method，with 45 cases in each group. Two cases dropped out from the control group. The trial group was treated with Shugan Jieyu Prescription， and the control group was treated with Sildenafil Citrate Tablets. The administration lasted for eight weeks. The changes of Internation Index of Erectile Function(IIEF- 5) scores including question 3 and question 4， Chinese medicine syndrome scores and Self- rating Anxiety Scale (SAS) after four and eight weeks of treatment were compared between the two groups. The clinical effects and the incidence of adverse reactions in the two groups were observed. Results： After four and eight weeks of treatment， scores of question 3 and 4 in IIEF- 5 in the two groups were increased when compared with those before treatment，and the two scores in the trial group were higher than those in the control group in the same period，the difference being significant(P＜0.05). After four and eight weeks of treatment，IIEF-5 scores in the two groups were increased when compared with those before treatment， and the IIEF-5 scores in the trial group were higher than those in the control group in the same period，the difference being significant(P＜0.05). After treatment， traditional Chinese medicine(TCM) scores of decreased sexual desire，emotional depression，abdominal distension，and loose stool in the two groups were decreased when compared with those before treatment；after eight weeks of treatment，each TCM syndrome score in the trial group was lower than that in the control group，the difference being significant (P＜0.05). After four and eight weeks of treatment，SAS scores in the two groups were decreased when compared with those before treatment(P＜0.05)，and SAS score in the trial group was lower than that in the control group in the same period(P＜0.05). According to Ridit analysis，the clinical effect in the trial group was better than that in the control group，the difference being significant(P＜0.05). There was no obvious adverse reaction in the two groups during the treatment. Conclusion：Shugan Jieyu Prescription has effects in relieving clinical symptoms of ED patients of liver depression and qi stagnation type， improving their erectile function and allaying anxiety and other negative emotions.