Abstract： Objective： To observe the clinical effect of Bushen Naqi Prescription combined with glucocorticoid for primary nephrotic syndrome. Methods： A total of 96 cases of patients with primary nephrotic syndrome were selected and divided into the control group and the observation group according to the random number table method，with 48 cases in each group. Both groups were given low-salt，low-fat and high-quality protein diet，and routine treatment for detumescence and diuresis，reducing blood lipid， anti-infection ， and anticoagulation. Based on routine treatment ， the control group was treated with glucocorticoid，and the observation group was additionally treated with Bushen Naqi Prescription based on the treatment of the control group. The clinical effects in the two groups were evaluated. Before and after treatment，the levels of 24- hour urinary protein，plasma albumin，soluble triggering receptor expressed on myeloid cells- 1(sTREM- 1)， immunoglobulin A(IgA)， and immunoglobulin M(IgM) in the two groups were detected. Results：The total effective rate was 95.83% in the observation group，higher than that of 79.17% in the control group， the difference being statistically significant(P＜0.05). After treatment， the 24-hour urinary protein levels in the two groups were decreased when compared with those before treatment， and the plasma albumin levels were increased(P＜0.05)； the 24- hour urinary protein level in the observation group was lower and the plasma albumin level was higher than those in the control group (P＜0.05). After treatment， the levels of serum sTREM- 1 in the two groups were decreased when compared with those before treatment， and the level of serum sTREM- 1 in the observation group was lower than that in the control group(P＜0.05)；the levels of IgA and IgM in the two groups were increased when compared with those before treatment，and the levels of IgA and IgM in the observation group were higher than those in the control group(P＜0.05). Conclusion： Bushen Naqi Prescription assisting the treatment for patients with primary nephrotic syndrome can inhibit the expression of sTREM- 1， and improve immune function，lung function and curative effect.