Abstract： Objective： To observe the effect of Shenduning Prescription combined with conventional western medicine on the kidney function，inflammatory factors and Chinese medicine syndrome scores in patients with stage 3-4 chronic renal failure with qi deficiency and blood stasis syndrome. Methods：A total of 120 patients with stage 3-4 chronic renal failure with qi deficiency and blood stasis syndrome were selected and divided into the observation group and the control group according to the random number table method，with 60 cases in each group. The control group was treated with conventional western medicine， and the observation group was treated with Shenduning Prescription based on the treatment of the control group. The Chinese medicine syndrome scores， kidney function， immune function and levels of inflammatory factors were compared between the two groups. Results： After treatment， the levels of blood urea nitrogen(BUN)，serum creatinine(SCr) and uric acid(UA) were decreased，and the endogenous creatinine clearance rates(CCr) were increased in the two groups(P＜0.05). After treatment， the levels of BUN，SCr and UA in the observation group were lower and the CCr was higher than those in the control group(P＜0.05). After treatment，the levels of CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment， and the levels of CD8 + were decreased(P＜0.05)； the levels of CD4+ and CD4+/CD8+ in the observation group were higher and the CD8+ level was lower than those in the control group(P＜0.05). After treatment， the levels of immunoglobulin(IgM， IgG， IgA) in the observation group were higher than those in the control group(P＜0.05). The levels of C-reactive protein(CRP)，tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in the two groups after treatment were decreased when compared with those before treatment(P＜0.05)，and the degree of reduction in the observation group was higher than that in the control group(P＜0.05). Conclusion： The therapy of Shenduning Prescription combined with conventional western medicine has effects in improving the kidney function and clinical symptoms，improving immunity and reducing inflammation in patients with stage 3-4 chronic renal failure with qi deficiency and blood stasis syndrome.