康复新液治疗幽门螺杆菌相关十二指肠溃疡临床研究
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R743

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Clinical Study on Kangfuxin Liquid for Duodenal Ulcer Associated with Helicobacter Pylori
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    摘要:

    目的:观察康复新液治疗幽门螺杆菌(Hp) 相关十二指肠溃疡的临床疗效。方法:采用随机数字表法将70 例Hp 相关十二指肠溃疡患者分成观察组与对照组各35 例。对照组给予常规疗法治疗,观察组在对照组基础上加用康复新液治疗。比较2 组治疗前后中医证候积分、白细胞介素-8 (IL-8)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP) 及肿瘤坏死因子-α(TNF-α) 水平;比较2 组Hp 根除率、复发率,并评价2 组临床疗效及不良反应发生情况。结果:治疗后,观察组总有效率及Hp 根除率高于对照组(P<0.05),复发率低于对照组(P<0.05)。治疗后,2 组中医证候积分、IL-6、IL-8、hs-CRP 及TNF-α水平均较治疗前降低(P<0.05),且观察组上述指标改善优于对照组(P<0.05)。2 组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:康复新液治疗Hp 相关十二指肠溃疡疗效显著,能够显著提高患者Hp根除率,降低炎症因子水平。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Kangfuxin Liquid for duodenal ulcer associated with helicobacter pylori(Hp). Methods:A total of 70 cases of patients with duodenal ulcer associated with Hp were divided into the observation group and the control group according to the random number table method, with 35 cases in each group. The control group was treated with routine therapy, and the observation group was additionally treated with Kangfuxin Liquid based on the treatment of the control group. The traditional Chinese medicine(TCM) syndrome scores and the levels of interleukin- 8(IL- 8), interleukin-6(IL-6), high-sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor- α(TNF-α) in the two groups were compared before and after treatment;the eradication rates and recurrence rates of Hp were compared between the two groups;the clinical effects and adverse reactions in the two groups were evaluated. Results: After treatment, the total effective rate and the eradication rate of Hp in the observation group were higher than those in the control group(P<0.05),and the recurrence rate was lower than that in the control group(P<0.05). After treatment, TCM syndrome scores and the levels of IL- 6, IL-8,hs-CRP and TNF-α in the two groups were decreased when compared with those before treatment (P<0.05),and the improvement of the above indexes in the observation group was superior to that in the control group(P<0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Kangfuxin Liquid for duodenal ulcer associated with Hp has a significant curative effect and can significantly improve the eradication rate of patients with Hp and reduce the levels of inflammatory factors.

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汪竹峰.康复新液治疗幽门螺杆菌相关十二指肠溃疡临床研究[J].新中医,2022,54(21):92-95

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  • 在线发布日期: 2022-11-15
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