苏黄汤联合常规西药治疗咳嗽变异性哮喘临床研究
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R725.6

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Clinical Study on Suhuang Tang Combined with Routine Western Medicine for Cough Variant Asthma
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    摘要:

    目的:观察苏黄汤联合常规西药治疗咳嗽变异性哮喘的临床疗效。方法:选取80 例咳嗽变异性哮喘患者,按随机数字表法分为观察组和对照组各40 例。对照组采用常规西药治疗,观察组在对照组基础上给予苏黄汤口服。比较2 组不同时间点肺功能、血清指标及中医证候积分。结果:治疗1 周、2 周后,2 组中医证候积分逐渐降低(P<0.05),且观察组中医证候积分均低于同时间点对照组(P<0.05)。治疗1 周、2 周后,2 组血清免疫球蛋白E(IgE)、白细胞介素-5(IL-5)、肿瘤坏死因子-α(TNF-α) 水平逐渐降低,白细胞介素-2(IL-2)、干扰素-γ(IFN-γ) 水平逐渐升高(P<0.05);且观察组血清IgE、IL-5、TNF-α 水平低于同时间点对照组,IL-2、IFN-γ 水平高于同时间对照组(P<0.05)。治疗1 周、2 周后,2 组最大呼气流量(PEF)、第1 秒用力呼气容积(FEV1)、用力肺活量(FVC) 水平较治疗前逐渐升高(P<0.05),且观察组PEF、FEV1、FVC 水平均高于同时间点对照组(P<0.05)。结论:苏黄汤联合常规西药治疗咳嗽变异性哮喘疗效显著,可改善临床症状,降低炎症反应,提高肺功能。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Suhuang Tang combined with routine western medicine for cough variant asthma. Methods: A total of 80 cases of patients with cough variant asthma were selected and divided into the observation group and the control group according to the random number table method,with 40 cases in each group. The control group was treated with routine western medicine, and the observation group was additionally given oral administration of Suhuang Tang based on the treatment of the control group. The lung function,serum indexes and Chinese medicine syndrome scores at different time points in the two groups were compared. Results:After one and two weeks of treatment, the Chinese medicine syndrome scores in the two groups were gradually decreased(P<0.05), and the Chinese medicine syndrome scores in the observation group were lower than those in the control group at the same time point(P<0.05). After one and two weeks of treatment,the levels of immunoglobulin E(IgE), interleukin- 5(IL- 5) and tumor necrosis factor- α(TNF- α) in serum in the two groups were gradually decreased(P<0.05),and the levels of interleukin-2(IL-2) and interferon-γ(IFN-γ) were gradually increased (P<0.05);the levels of IgE,IL-5 and TNF-α in serum in the observation group were lower and the levels of IL-2 and IFN-γ were higher than those in the control group at the same time point(P<0.05). After one and two weeks of treatment, the levels of peak expiratory flow(PEF), forced expiratory volume in one second(FEV1) and forced vital capacity(FVC) in the two groups were gradually increased(P<0.05),and the levels of PEF,FEV1 and FVC in the observation group were higher than those in the control group at the same time point(P<0.05). Conclusion: Suhuang Tang combined with routine western medicine has a significant curative effect in treating cough variant asthma,which can improve clinical symptoms,reduce inflammatory responses and enhance lung function.

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江君萍,蔡高翔,陆维宏.苏黄汤联合常规西药治疗咳嗽变异性哮喘临床研究[J].新中医,2022,54(21):76-79

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  • 在线发布日期: 2022-11-15
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