Abstract： Objective： To observe the clinical effect of modified Dachaihu Tang combined with liraglutide for obese type 2 diabetes and its effects on high- sensitivity C- reactive protein(hs- CRP). Methods： A total of 104 cases of patients with obese type 2 diabetes were divided into the observation group and the control group according to the random number table method，with 52 cases in each group. The control group was treated with liraglutide，and the observation group was treated with Dachaihu Tang and liraglutide. The traditional Chinese medicine(TCM) syndrome scores and levels of inflammatory factors before and after treatment，clinical effects and the incidence of adverse reactions were compared between the two groups. Results： After treatment， the total effective rate was 90.4% in the observation group， higher than that of 75.0% in the control group(P＜0.05). There was no significant difference in blood glucose indexes between the two groups before treatment(P＞0.05). After treatment，fasting blood glucose(FBG)， 2- hours postprandial blood glucose(P2hBG)， glycosylated hemoglobin(HbA1c) in the two groups were decreased compared with those before treatment(P＜0.05)，and the indexes in the observation group were lower than those in the control group(P＜0.05). After treatment， the TCM syndrome scores including epigastric fullness，chest rib distension，vexation and irascibility，dry mouth and bitter taste，constipation， and obesity in the two groups were decreased when compared with those before treatment(P＜0.05)；and each TCM syndrome score after treatment in the observation group was lower than that in the control group (P＜0.05). After treatment，levels of tumor necrosis factor-α(TNF-α)，interleukin-6(IL-6) and hs-CRP in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and the three levels in the observation group were lower than those in the control group(P＜0.05). There was no statistically significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： Modified Dachaihu Tang combined with liraglutide has a good clinical effect in the treatment of obese type 2 diabetes，which helps to improve clinical symptoms and reduce levels of inflammatory factors in body with high safety.