Abstract： Objective： To discuss the rules of prescriptions with medicine food homology for dysmenorrhea based on data mining. Methods： The literature on Chinese medicine treatment of dysmenorrhea was retrieved from China National Knowledge Infrastructure(CNKI)， Wanfang Data (Wanfang)， Chinese Scientific Journals Database(VIP)， and Chinese Biomedical Databases(CBM). SPSS， Cytospace 3.8.2 and other softwares were used to analyze the frequency，properties，flavors，meridian tropism， function category， association rules and clustering of Chinese medicines and medicines of medicinal and edible homology for treating dysmenorrhea. Results： A total of 765 prescriptions were included，involving 270 Chinese medicines and 65 Chinese medicines of medicine food homology. Chinese medicines of medicinal and edible homology included Angelicae Sinensis Radix， Glycyrrhizae Radix et Rhizoma， Persicae Semen， and Cinnamomi Cortex； common Chinese medicinals included Angelicae Sinensis Radix，Chuanxiong Rhizoma，Corydalis Rhizoma，and Glycyrrhizae Radix et Rhizoma. Most of the Chinese medicines used in the clinical treatment of dysmenorrhea were blood- tonifying medicines and blood- activating and pain- relieving medicines， with the nature of warmth， cold， and balanced， the flavors of pungency，bitterness，and sweetness，and the meridian entry of the spleen meridian，the heart meridian，and the liver meridian. Most of the Chinese medicines of medicinal and edible homology used in the clinical treatment of dysmenorrhea were qi-tonifying and blood-enriching medicines，with the nature of warmth and balanced，the flavors of pungency，and sweetness，and the meridian entry of the spleen meridian，the heart meridian，and the liver meridian. Common couplet medicinals were Angelicae Sinensis Radix- Chuanxiong Rhizoma and Angelicae Sinensis Radix- Paeoniae Radix Alba. Common couplet medicines of medicinal and edible homology were Angelicae Sinensis Radix- Glycyrrhizae Radix et Rhizoma and Angelicae Sinensis Radix-Cinnamomi Cortex. Five core combinations of Chinse medicines were obtained by cluster analysis， and their main effects were： moving qi and removing blood stasis to relieve pain， soothing the liver and resolving depression to relieve pain，and activating blood and removing blood stasis to relieve pain. Five core combinations of Chinse medicines of medicinal and edible homology were obtained， and their main effects were： supplementing the liver and kidney， tortifying the spleen and replenishing qi， and tonifying the spleen and kidney. Conclusion： Chinese medicines of medicinal and edible homology for dysmenorrhea are usually medicines for qi- blood supplementing. In clinical practice， combinations including Angelicae Sinensis Radix-Glycyrrhizae Radix et Rhizoma ， and Angelicae Sinensis Radix-Cinnamomi Cortex are commonly used. The main treatment methods are regulating and tonifying the body constituation by supplementing qi and nourishing blood， assisted by warming the interior and activating blood to relieve pain.