Abstract：This paper introduces the clinical experience of Prof. LI Xueming in treating IgA nephropathy. Prof. LI attaches great importance to the application of the theory in Huangdi Neijing during the treatment of IgA nephropathy. He believes that IgA nephropathy is closely related to the lung， spleen and kidney and adopts the method of combining Chinese and western medicine with the main focus on the former and the help from the latter to guide the diagnosis and treatment IgA nephropathy. He classifies IgA nephropathy into five types according to five main syndrome types， namely wind pathogen invading the lung， latent heat in the lung and stomach，lung-spleen qi deficiency，spleen-kidney yang deficiency and liver-kidney yin deficiency. And there are five main treatment methods which are diffusing the lung and clearing heat， clearing heat and pacifying blood， supplementing the lung and spleen， warming and supplementing the spleen and kidney and enriching and supplementing the liver and kidney. In addition，he also thinks that if there are no obvious symptoms except abnormal results of urine routine examination during treatment，we should pay attention to the disease identification as a supplement based on the syndrome differentiation， and comprehensively analyze the etiology and pathogenesis through physical and chemical examination and clinical symptoms. As for the patients who have been treated with hormones，we should pay attention to identifying the essence of its pathogenesis and apply Chinese medicine to enhance the efficacy and reduce the toxin.