Abstract： This paper introduces the clinical experience of syndrome differentiation and treatment of chronic kidney disease with Shenwu Yishen prescription under the guidance of Director TIAN Bingzhao. TIAN Bingzhao stressed that， in the treatment of chronic kidney disease with Chinese medicine， the analysis should be carried out based on the basic theory of Huangdi Neijing，so as to find out the etiology and pathogenesis；he also pointed out that transportation and transformation that are both governed by the spleen are closely related and slightly different， therefore， careful consideration is a must during diagnosis，treatment，and medication. TIAN repeatedly warned that the use of Chinese medicinals must follow the basic principles including the concept of holism， syndrome differentiation and treatment， and seeking the root when treating disease，and should not only keep eyes on “creatinine” and "proteinuria" and then turn to the so- called specific medicine. Shenwu Yishen prescription was originally used by Professor ZOU Yunxiang，a leading kidney disease expert，to treat chronic nephritis and renal failure；it is a famous prescription for the syndrome of qi-yin deficiency；with neutral and bland medicinal flavor，it can treat lingering diseases. Under the guidance of TIAN，this paper explored the usage of various medicinals in Shenwu Yishen prescription. The results showed that chronic kidney disease should belong to the syndrome of the spleen-kidney qi deficiency and the kidney yin deficiency，or mixed with blood stasis，phlegm，and