Abstract： Objective： To study the clinical effect of thermotherapy combined with AP scheme (pemetrexed and carboplatin) and Endostar for advanced non-small cell lung cancer(NSCLC)，and its effect on levels of tumor markers in serum， vascular endothelial growth factor(VEGF)， basic fibroblast growth factor(bFGF) and platelet- derived growth factor(PDGF) as well as quality of life. Methods ： A total of 290 cases of patients with advanced NSCLC were selected as the study subjects and divided into two groups according to the random number table method， with 145 cases in each group. The control group was treated with AP scheme combined with Endostar，and the observation group was additionally treated with thermotherapy based on the treatment of the control group. After four courses of treatment， the short- term curative effect in the two groups were observed. Before and after treatment， the levels of tumor markers in serum including carcinoembryonic antigen(CEA)， carbohydrate antigen 125(CA125)， cytokeratin 19 fragment antigen 21-1(CYFRA21-1) and squamous cell carcinoma antigen(SCC Ag)，as well as levels of pro-angiogenic factors including VEGF，bFGF and PDGF in the two groups were detected，and the quality of life was evaluated by Functional Assessment of Cancer Therapy-Lung(FACT-L). The incidence of toxicity and side effects in the two groups was recorded and compared. Results：The objective effective rate was 57.93%(84/145) in the observation group and 41.38%(60/145) in the control group，the difference being significant(P＜0.05). After treatment，the levels of CEA，CA125，CYFRA21-1 and SCC-Ag in serum in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)， and the levels in the observation group were significantly lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of VEGF， bFGF and PDGF in serum in the two groups were decreased when compared with those before treatment， differences being significant(P＜0.05)， and the concentration of VEGF， bFGF and PDGF in serum in the observation group was lower than that in the control group， differences being significant(P＜0.05). After treatment，the scores of physiological status，emotion state，exercise capacity and additional attention in FACT-L in the observation group were increased when compared with those before treatment，differences being significant(P＜0.05)；there was no significant difference being found in the comparison of the scores in FACT-L in the observation group before and after treatment(P＞0.05)；there was significant differences being found in the comparison of the scores in all dimensions in FACT-L except the scores of social/home situation between the two groups(P＜0.05). There was no significant difference being found in the comparison of the incidence of toxicity and side effects including gastrointestinal reactions， myelosuppression and peripheral neurotoxicity between the two groups(P＞0.05). Conclusion：Thermotherapy combined with AP scheme and Endostar for advanced NSCLC can effectively inhibit the expression levels of tumor markers in serum and pro-angiogenic factors，and improve quality of life with a significant short-term curative effect and good safety