基于中医传承辅助平台研究潘俊辉辨治肺癌用药规律
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R734.2;R249

基金项目:

广东省名中医潘俊辉传承工作室建设项目


Administration Rule of PAN Junhui in Differentiating and Treating Lung Cancer Based on Chinese Medicine Inheritance Auxiliary Platform
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:基于中医传承辅助平台研究潘俊辉教授治疗肺癌的用药规律,为制定“岭南平治肺病”的肺癌治疗方案提供参考。方法:收集2019 年5 月—2021 年4 月潘俊辉教授在门诊治疗肺癌的医案资料,按照纳入标准与剔除标准筛选后录入中医传承辅助平台V2.5,建立资料库,并进行系统分析。统计用药频率;运用Apriori 算法和关联规则分析提取处方的核心组合(设置支持度0.45,置信度0.8);运用复杂系统聚类分析对内部核心药物组合与新方组合(设关联度12,惩罚度7) 进行挖掘。结果:共纳入163 份医案,共计796 首方,涉及150 味中药。单味药物频次前10 位者,从高到低依次是红景天、紫河车、炙甘草、醋莪术、瓜蒌皮、薤白、姜半夏、淫羊藿、黄芪、白术。核心药物组合中高频组合前10 位,从高到低依次是:炙甘草-紫河车,炙甘草-红景天,瓜蒌皮-紫河车,瓜蒌皮-薤白,瓜蒌皮-红景天,姜半夏-红景天,紫河车-薤白,紫河车-红景天,紫河车-醋莪术,薤白-红景天;其中,红景天、紫河车、瓜蒌皮、薤白、醋莪术、炙甘草、姜半夏等在多个药物组合中多次出现,为关联网络的核心。获得潜在新方10 首,包括薏苡仁-苇根-桃仁-地骨皮-冬瓜子、熟党参-薤白-广升麻-北柴胡-姜半夏-瓜蒌皮、白芍-熟地黄-紫菀-桃仁-红花-酒川芎等。结论:潘俊辉教授临床辨证论治肺癌以扶正祛邪为原则。以温肾清肺为根本治疗大法,辅以化瘀软坚散结、活血健脾补气、祛风通络化痰。

    Abstract:

    Abstract:Objective:To study the administration rule of Prof. PAN Junhui in differentiating and treating lung cancer based on the Chinese Medicine Inheritance Auxiliary Platform,so as to provide reference for designing the treatment of lung cancer by "treating lung cancer from the neutral in Lingnan area". Methods: The medical records of Prof. PAN in treating lung cancer in the outpatient department from May 2019 to April 2021 were collected, screened according to the inclusion criteria and exclusion criteria, and then entered into the Chinese Medicine Inheritance Auxiliary Platform V2.5 to establish a database and conduct systematic analysis. The medication frequency was counted;Apriori algorithm and association rules were used to analyze and extract the core combination of prescriptions(support set as 0.45,confidence as 0.8); complex system cluster analysis was used to mine the internal core herbal combination and new prescription combination(correlation set as 12,penalty as 7). Results:A total of 163 medical records were included,with a total of 796 prescriptions involving 150 kinds of Chinese herbs. The top 10 most frequently used herbs were Radix et Rhizoma Rhodiolae Crenulatae, Placenta Hominis, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle,acetous Rhizoma Curcumae,Pericarpium Trichosanthis,Bulbus Allii Macrostemi, Rhizoma Pinelliae Praeparatum, Herba Epimedii, Radix Astragali and Rhizoma Atractylodis Macrocephalae. The top 10 high- frequency herbal combinations in core herbal combinations from high to low were Radix et Rhizoma Glycyrrhizae Praeparata cum Melle- Placenta Hominis, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle- Radix et Rhizoma Rhodiolae Crenulatae, Pericarpium Trichosanthis- Placenta Hominis,Pericarpium Trichosanthis-Bulbus Allii Macrostemi,Pericarpium Trichosanthis-Radix et Rhizoma Rhodiolae Crenulatae, Rhizoma Pinelliae Praeparatum- Radix et Rhizoma Rhodiolae Crenulatae, Placenta Hominis- Bulbus Allii Macrostemi, Placenta Hominis- Radix et Rhizoma Rhodiolae Crenulatae, Placenta Hominis- acetous Rhizoma Curcumae, Bulbus Allii Macrostemi- Radix et Rhizoma Rhodiolae Crenulatae; among them, Radix et Rhizoma Rhodiolae Crenulatae, Placenta Hominis, Pericarpium Trichosanthis, Bulbus Allii Macrostemi, acetous Rhizoma Curcumae, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle, and Rhizoma Pinelliae Praeparatum appeared many times in multiple herbal combinations, which were the core of the associated network. A total of 10 potential new prescriptions were obtained, including Semen Coicis- Rhizoma Phragmitis- Semen Persicae- Cortex Lycii- Semen Benincasae, mature Radix Codonopsis- Bulbus Allii Macrostemi- Guangdong Rhizoma Cimicifugaenorthern Radix Bupleuri-Rhizoma Pinelliae Praeparatum-Pericarpium Trichosanthis,Radix Paeoniae Alba- Radix Rehmanniae Praeparata-Radix et Rhizoma Asteris-Semen Persicae-Flos Carthami-vinous Rhizoma Chuanxiong. Conclusion: Prof. PAN's clinical syndrome differentiation and treatment of lung cancer is based on the principle of reinforcing healthy qi and dispelling pathogenic factors. He takes warming the kidney and clearing the lung as the fundamental treatment,supplemented by dissolving stasis,softening hard masses and dissipating masses,invigorating blood,fortifying the spleen and supplementing qi,and dispelling wind,unblocking the collaterals and dissolving phlegm.

    参考文献
    相似文献
    引证文献
引用本文

黄语婷,邓颖敏,黄彭珍,蔡贝贝,柯宏霞,王鹏,指导:潘俊辉.基于中医传承辅助平台研究潘俊辉辨治肺癌用药规律[J].新中医,2022,54(20):131-136

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2022-10-28
  • 出版日期:
文章二维码