Abstract： Objective： To observe the clinical effect of the therapy of Xiongdan- powder eye drops combined with tacrolimus on catarrh conjunctivitis. Methods： A total of 80 patients with catarrh conjunctivitis were enrolled and divided into the control group and the study group according to random number table method，with 40 cases in each group. Both groups were treated with tacrolimus eye drops， and the study group was additionally treated with Xiongdan- powder eye drops based on the treatment of the control group. The total clinical effective rates， disappearance time of symptoms， cure time of symptoms and the incidence of adverse reactions were observed and compared between the two groups， and the changes of scores of symptoms and signs were counted before and after treatment. Results：The total effective rate was 92.50% in the study group and 77.50% in the control group，the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the scores of symptoms and signs such as tearing，eye itching，dislike of heat and photophobia，sensation of foreign body， follicles， nipples， redness of sclera and red and swelling eyelid(P＞0.05)； after treatment， the above scores in the two groups were significantly decreased when compared with those before treatment， and the above scores in the study group were lower than those in the control group，the difference being significant(P＜0.05). After treatment， the disappearance time and average cure time of tearing， eye itching，dislike of heat and photophobia and sensation of foreign body in the study group were shorter than those in the control group， the difference being significant(P＜0.05). The incidence of adverse reactions was 7.50% in the study group and 5.00% in the control group， there being no significant difference between the two groups(P＞0.05). Conclusion：The therapy of Xiongdan-powder eye drops combined with tacrolimus has a better therapeutic effect than tacrolimus alone on the treatment of catarrh conjunctivitis， which can rapidly improve the clinical symptoms and signs of patients with good safety.