醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻临床研究
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Clinical Study on Xingpi Yang'er Granules Combined with Clostridium Butyricum Powder for Dyspepsia-Induced Diarrhea in Children
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    摘要:

    目的:观察醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻的临床疗效。方法:选取122例消化不良性腹泻患儿,按照随机数字表法分为联合组和对照组各61例,其中对照组剔除1例中途转院者,最终纳入60例。对照组给予酪酸梭菌活菌散治疗,联合组在对照组基础上加用醒脾养儿颗粒治疗,2组均治疗3 周。比较2 组临床疗效、临床症状缓解时间、胃肠激素及免疫功能指标。结果:联合组总有效率96.72%,高于对照组86.67%(P<0.05)。联合组腹痛腹胀、早饱、厌食、恶心呕吐、腹泻缓解时间均短于对照组(P<0.05)。治疗后,2组血清胃泌素(GAS) 与血浆胃动素(MOT)、二胺氧化酶(DAO) 水平均较治疗前降低(P<0.05),血浆生长抑素(SS) 水平均较治疗前升高(P<0.05);联合组血清GAS与血浆MOT、DAO水平均低于对照组(P<0.05),血浆SS水平高于对照组(P<0.05)。治疗后,2组CD3+、CD4+水平及CD4+/CD8+值均较治疗前升高(P<0.05),CD8+水平均较治疗前降低(P<0.05);联合组CD3+、CD4+水平及CD4+/CD8+值均高于对照组(P<0.05),CD8+水平低于对照组(P<0.05)。结论:醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻,可有效缓解患儿的临床症状,调节胃肠激素水平,提高免疫功能。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Xingpi Yang'er granules combined with Clostridium butyricum powder on dyspepsia-induced diarrhea in children. Methods:A total of 122 cases of children with dyspepsia- induced diarrhea were selected and assigned to the control group and the combination group according to the random number table method,with 61 cases in each group,and one case in the control group was excluded. The control group was treated with Clostridium butyricum powder, and the combination group was additionally treated with Xingpi Yang'er granules on the basis of the control group. Both groups were treated for three weeks. The clinical effects, clinical symptom remission time, gastrointestinal hormones and immune function indexes were compared between the two groups. Results: The total effective rate was 96.72% in the combination group, higher than that of 86.67% in the control group(P<0.05). The remission time of abdominal pain and distension,early satiety,anorexia,nausea and vomiting and diarrhea in the combination group were shorter than those in the control group(P<0.05). After treatment,the levels of serum gastrin(GAS) and plasma motilin(MOT) and diamine oxidase(DAO) in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of plasma somatostatin(SS) were increased when compared with those before treatment(P<0.05); the levels of serum GAS and plasma MOT and DAO in the combination group were lower than those in the control group (P<0.05),and the level of plasma SS was higher than that in the control group(P<0.05). After treatment, the levels of CD3 +,CD4 + and CD4 +/CD8 + in the two groups were increased when compared with those before treatment(P<0.05),and the levels of CD8 + were decreased(P<0.05);the levels of CD3 +,CD4 + and CD4 +/CD8 + in the combination group were higher than those in the control group(P<0.05), and the level of CD8 + was lower than that in the control group(P<0.05). Conclusion: Xingpi Yang'er granules combined with Clostridium butyricum powder for dyspepsia- induced diarrhea in children can effectively relieve their clinical symptoms,regulate gastrointestinal hormones,and improve immune function,with good safety.

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马国靖,吴银,程刚.醒脾养儿颗粒联合酪酸梭菌活菌散治疗小儿消化不良性腹泻临床研究[J].新中医,2022,54(20):115-118

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  • 在线发布日期: 2022-10-28
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