Abstract：Objective：To observe the clinical effect of Niaoduqing granules combined with levocarnitine injection for chronic kidney failure. Methods：A total of 70 cases of patients with chronic kidney failure in early and middle stage with the spleen- kidney qi deficiency syndrome were randomly divided into the control group and the treatment group， with 35 cases in each group. Both groups were given routine intervention measures；the control group was treated with levocarnitine injection，and the treatment group was additionally treated with Niaoduqing granules based on the treatment of the control group. Both groups were treated for three months. Changes in the kidney function indexes and scores of the spleen-kidney qi deficiency syndrome before and after treatment and total clinical effects after treatment in the two groups were observed and compared. Results：The total effective rate was 88.57% in the treatment group，and 65.71% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference in serum creatinine(SCr)，blood urea nitrogen(BUN) and 24-hour urine protein(24hUP) between the two groups(P＞0.05). After treatment，the above three indexes of the two groups were lower than those before treatment(P＜0.05)， and the above three indexes in the treatment group were significantly lower than those in the control group(P＜0.05). Before treatment， there was no significant difference in the scores of spleen-kidney qi deficiency syndrome and total points between the two gruops (P＞0.05). After treatment， total points and the scores of fatigue and lack of strength， short breath and laziness to speak， torpid intake， soreness and weakness of waists and knees， gastric stuffiness and fullness， soft stool， and bland taste in the mouth and no thirst in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the above scores in the treatment group were significantly lower than those in the control group(P＜0.05). Conclusion： Based on routine western medicine treatment，the application of Niaoduqing granules combined with levocarnitine injection for chronic kidney failure with the spleen- kidney qi deficiency syndrome can further improve the kidney function，Chinese medicine syndromes and clinical effects.