Abstract：Objective：To observe the clinical effect of the therapy of formula granules of Sanzi Yangqin tang combined with Shenling Baizhu powder on acute exacerbation of chronic obstructive pulmonary disease (COPD) with turbid phlegm obstructing the lung syndrome. Methods： A total of 120 patients with acute exacerbation of COPD with turbid phlegm obstructing the lung syndrome were divided into the control group and the observation group according to the random number table method，with 60 cases in each group. The control group was treated with routine basic treatment of western medicine and the observation group was additionally treated with formula granules of Sanzi Yangqin tang combined with Shenling Baizhu powder based on the treatment of the control goup. Both groups were treated for one week continuously. The clinical effects，Chinese medicine syndrome scores，scores of COPD Assessment Test(CAT) and modified Medical Research Council(mMRC) scale and changes of indexes of pulmonary ventilation function， including forced vital capacity(FVC)，forced expiratory volume in one second(FEV1)，FEV1/FVC，and content of indexes related to airway damage，including serum procalcitonin(PCT) and C- reactive protein(CRP)，in the two groups were analyzed and compared. Results： During the treatment， 5 cases fell of in the observation group and 4 cases fell of in the control group. The total effective rate was 94.55% in the observation group and 78.57% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparisons of syndrome scores of expectoration， panting and cough and chest oppression between the two groups(P＞0.05)； after treatment， the syndrome scores of expectoration， panting and cough and chest oppression in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of scores of CAT and mMRC between the two groups(P＞0.05)； after treatment， the scores of CAT and mMRC were decreased when compared with those before treatment(P＜0.05)， and the above two scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparisons of levels of FVC，FEV1 and FEV1/FVC between the two groups(P＞0.05)；after treatment， the levels of FVC，FEV1 and FEV1/FVC in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three indexes of pulmonary ventilation function in the observation group were significantly higher than those in the control(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of serum PCT and CRP between the two groups(P＞ 0.05)； after treatment， the levels of serum PCT and CRP in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above two levels in the observation group was lower than those in the control group(P＜0.05). Conclusion： The therapy of formula granules of Sanzi Yangqin tang combined with Shenling Baizhu powder for acute exacerbation of COPD with turbid phlegm obstructing the lung syndrome can relieve the clinical symptoms， improve the pulmonary ventilation function，and effectively reduce the inflammatory responses.