Abstract：Objective：To observe the clinical effect of the therapy of Jianpi Gushen granules combined with routine therapy of modern medicine on children with recurrent respiratory tract infection with spleenkidney deficiency syndrome. Methods： A total of 90 children with recurrent respiratory tract infection of spleen-kidney deficiency type were selected and divided into the control group and the observation group according to the random number table method，with 45 cases in each group. The control group was given routine therapy of modern medicine， and the observation group was additionally given Jianpi Gushen granules orally based on the treatment of the control group. The clinical effects and adverse reactions in the two groups were observed. Before and after treatment， the changes of Chinese medicine syndrome scores，lung function，including forced vital capacity(FVC)，peak expiratory flow(PEF) and forced expiratory volume in one second(FEV1)，levels of inflammatory factors，including serum tumor necrosis factor-α(TNF- α)， interleukin- 4(IL- 4) and serum C- reactive protein(CRP)， and indexes of immune function， including immunoglobulin A(IgA)，immunoglobulin G(IgG)，immunoglobulin M(IgM) and T cell subsets(CD3+，CD4+， CD8 + and CD4 +/CD8 + ) were compared between the two groups. Results： After treatment， the clinical effect was 93.33% in the observation group and 77.78% in the control group， the difference being significant(P＜0.05). After treatment， the Chinese medicine syndrome scores of cough and excessive phlegm， dyspnea， lassitude of spirit and lack of strength， torpid intake and shortage of qi and disinclination to talk in the two groups were decreased when compared with those before treatment，and the above five Chinese medicine syndrome scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the values of FVC，FEF and FEV1 in the two groups were increased when compared with those before treatment，and the above three values in the observation group were higher than those in the control group，differences being significant(P＜0.05). After treatment，the levels of TNF- α，CRP and IL-4 in the two groups were decreased when compared with those before treatment，and the above three levels in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the values of IgA，IgG，IgM， CD3 + ， CD4 + and CD4 +/CD8 + in the two groups were increased when compared with those before treatment，and the CD8+ values were decreased，differences being significant(P＜0.05)；after treatment， the values of IgA，IgG，IgM，CD3+，CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group，and the CD8+ value in the observation group was lower，differences being significant (P＜0.05). During treatment， no obvious adverse reactions were found in both groups. Conclusion： The therapy of Jianpi Gushen granules combined with routine therapy of modern medicine has a good clinical effect on children with recurrent respiratory tract infection of spleen- kidney deficiency type， which can improve the clinical symptoms，reduce the inflammatory responses，enhance the immune function of the body，and improve the lung function.