Abstract：Objective：To observe the curative effect of Xiaobi prescription combined with arthroscopic debridement on knee osteoarthritis of liver-kidney deficiency type. Methods：A total of 80 cases of patients with knee osteoarthritis were selected and divided into the observation group and the control group according to the random number table method，with 40 cases in each group. The control group was treated with arthroscopic debridement， routine medicine for analgesia and rehabilitation training， and the observation group was additionally treated with Xiaobi prescription based on the treatment of the control group. The clinical effects and safety in the two groups were observed. Before arthroscopic debridement and one and two months after arthroscopic debridement， the changes of Lysholm scores for knee joint function and Visual Analogue Scale(VAS) scores for pain were compared between the two groups. Results： One and two months after arthroscopic debridement，the Lysholm scores for knee joint function in the two groups were increased when compared with those before arthroscopic debridement，and the above score in the observation group was higher than that in the control group at the same time respectively， differences being significant(P＜0.05). One and two months after arthroscopic debridement，the Lysholm scores for knee joint function in the two groups were increased when compared with those before arthroscopic debridement，and the above score in the observation group was higher than that in the control group at the same time respectively，differences being significant(P＜0.05). After arthroscopic debridement， the total clinical effective rate was 95% in the observation group and 90% in the control group， the difference being significant(P＜0.05). After arthroscopic debridement， there was no significant difference being found in the comparison of treatment safety between the two groups(P＞0.05). Conclusion： The therapy of Xiaobi prescription combined with arthroscopic debridement has a good curative effect on knee osteoarthritis of liver-kidney deficiency type，which can improve the knee joint function after arthroscopic debridement and relieve the pain in knee joint.