Abstract： Objective： To observe the clinical effect of the therapy of Jianpi Huoxue Yishen tang on stage 3 chronic kidney disease complicated with carotid atherosclerosis and its effect on inflammatory factors. Methods： A total of 110 cases of patients with stage 3 chronic kidney disease complicated with carotid atherosclerosis were selected and divided into the observation group and the control group according to the random number table method， with 55 cases in each group. The control group was treated with Shenshuaining，and the observation group was additionally treated with Jianpi Huoxue Yishen tang based on the treatment of the control group. The clinical effects，incidence of adverse reactions and incidence of hyperkalemia in the two groups were compared between the two groups；before and after treatment，the levels of serum inflammatory factors， indexes of lung function， indexes of carotid artery ultrasound， Chinese medicine syndrome scores and levels of serum potassium were compared between the two groups. Results： After treatment， the total effective rate was 96.38% in the observation group， higher than that of 83.26% in the control group(P＜0.05). After treatment，the levels of interleukin-6(IL-6)，tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of inflammatory factors in the observation group were lower than those in the control group(P＜0.05). The levels of blood urea nitrogen(BUN) and serum creatinine (SCr) were decreased when compared with those before treatment(P＜0.05)，and the levels of creatinine clearance rate(CCr) were increased(P＜0.05)， and the improvement in indexes of kidney function was better than that in the control group(P＜0.05). After treatment， the numbers of plaque， Crouse carotid plaque scores and Chinese medicine syndrome scores and carotid artery intima- media thickness(CIMT) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of serum potassium were increased(P＜0.05)，and the improvement in the above indexes in the observation group was better than that in the control group(P＜0.05). The incidence of adverse reactions and incidence of hyperkalemia in the observation group were lower than those in the control group， there being no significance in the difference(P＞0.05). Conclusion：The therapy of Jianpi Huoxue Yishen tang has a definite curative effect on stage 3 chronic kidney disease complicated with carotid atherosclerosis， which can effectively improve the kidney function of patients，decrease the inflammatory responses and reduce the carotid atherosclerotic plaque，with high safety.