芪苈强心胶囊联合常规西药治疗慢性心力衰竭临床研究
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R541.6

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Clinical Study on Qili Qiangxin Capsules Combined with Routine Western Medicine for Chronic Heart Failure
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    摘要:

    目的:观察芪苈强心胶囊联合常规西药治疗慢性心力衰竭的临床疗效。方法:选取慢性心力衰竭患者100 例,按随机数字表法分为观察组和对照组各50 例。对照组给予常规西药治疗,观察组在对照组基础上给予芪苈强心胶囊治疗。比较2 组临床疗效、中医证候积分以及心功能指标。结果:观察组总有效率为95.00%,对照组为80.00%,2 组比较,差异无统计学意义(χ2=4.114,P>0.05)。治疗后,2 组中医证候积分较治疗前降低,且观察组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗后,2 组血清N 末端B 型利钠肽前体(NT-pro BNP) 水平以及左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD) 较治疗前降低, 且观察组血清NT-pro BNP 水平以及LVEDD、LVESD 均低于对照组(P<0.05); 2 组心脏指数(CI)、左室射血分数(LVEF)、心输出量(CO) 以及二尖瓣心室充盈早期血流速度峰值(E 峰) 与晚期心室充盈心房收缩血流速度峰值(A 峰) 比值(E/A) 较治疗前升高,且观察组CI、LVEF、CO 以及E/A 高于对照组(P<0.05)。结论:芪苈强心胶囊联合常规西药治疗慢性心力衰竭能够显著改善患者心功能,在一定程度上抑制左心室的重构,并有效减轻临床症状。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Qili Qiangxin capsules combined with routine western medicine on chronic heart failure. Methods:A total of 100 patients with chronic heart failure were divided into the observation group and the control group according to the random number table method,with 50 cases in each group. The control group was treated with routine western medicine,and the observation group was additionally treated with Qili Qiangxin capsules based on the treatment of the control group. The clinical effects, Chinese medicine syndrome scores and indexes of the heart function were compared between the two groups. Results:The total effective rate was 95.00% in the observation group and 80.00% in the control group,there being no significance in the difference(χ 2=4.114,P>0.05). After treatment, the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment, and the Chinese medicine syndrome score in the observation group were lower than that in the control group,the difference being significant(P<0.05). After treatment, the levels of serum N- terminal pro- brain natriuretic peptide(NT- pro BNP), left ventricular end- diastolic diameter(LVEDD) and left ventricular end- systolic diameter(LVESD) in the two groups were decreased when compared with those before treatment, and the above three levels in the observation group were lower than those in the control group(P<0.05); the cardiac index(CI), left ventricular ejection fraction (LVEF),cardiac output(CO) and the ratio of peak blood flow velocity of early mitral ventricular filling(Peak E) to peak blood flow velocity of late ventricular filling and atrial contraction(Peak A)(E/A) in the two groups were increased when compared with those before treatment,and the above four levels in the observation group were higher than those in the control group(P<0.05). Conclusion: The therapy of Qili Qiangxin capsules combined with routine western medicine for chronic heart failure can significantly improve the heart function, inhibit the left ventricular remodeling to a certain extent, and effectively reduce the clinical symptoms.

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薛晓波,印美,潘晓丹,黄才博.芪苈强心胶囊联合常规西药治疗慢性心力衰竭临床研究[J].新中医,2022,54(19):80-83

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  • 在线发布日期: 2022-10-08
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