Abstract ： Objective ： To observe the clinical effect of Xuefu Zhuyu tang on risperidone-induced hyperprolactinemia in female patients with schizophrenia. Methods： A total of 180 female schizophrenic patients with risperidone- induced hyperprolactinemia were divided into three groups by random number method，with 60 cases in each group. Group A was treated with risperidone alone；Group B was treated with risperidone combined with aripiprazole， and Group C was treated with risperidone combined with Xuefu Zhuyu tang. The clinical effects and prolactin levels，scores of Positive and Negative Symptom Scale (PANSS)，scores of Clinical General Impression(CGI)，scores of Rating Scale for Extrapyramidal Side Effects (RSESE) before and after treatment were compared between the three groups. Results： Compared with those before treatment，the serum prolactin levels in Groups B and C were decreased at the 2nd，4th，6th and 8th weekend of treatment(P＜0.05)；Compared with that in Group A at the 2nd，4th，6th and 8th weekend of treatment，the serum prolactin levels in Groups B and C were lower at the corresponding time points of treatment(P＜0.05)；Compared with that in Group B at the 2nd，4th，6th and 8th weekend of treatment，the serum prolactin level in Group C was lower at the corresponding time points of treatment(P＜0.05). Compared with those before treatment，the PANSS and CGI scores in Groups A，B and C were decreased at the 4th and 8th weekend of treatment(P＜0.05)；the PANSS and CGI scores in Groups B and C were lower than those in Group A at the 4th and 8th weekend of treatment(P＜0.05)；Compared with those in Group B at the 8th weekend of treatment，the PANSS and CGI scores in Group C were lower at the corresponding time points of treatment(P＜0.05). Compared with that before treatment，the RSESE scores in Groups A，B and C was respectively decreased at the 6th and 8th weekend of treatment(P＜0.05)；There was no significant difference in the comparison of the RSESE scores between the thee groups before treatment and at the corresponding time points at the 2nd， 4th， 6th and 8th weekend of treatment(P＞0.05). Conclusion： Xuefu Zhuyu tang has more advantages in improving risperidone- induced hyperprolactinemia in female patients with schizophrenia，and it is safe and reliable with little adverse reactions.