Abstract:Objective:To study the clinical experience of Director FENG Yi in the treatment of chronic obstructive pulmonary disease based on data mining analysis. Methods: A total of 1 602 clinical cases of FENG Yi treating chronic obstructive pulmonary disease were collected according to the inclusion criteria and were recorded by EpiData 3.1 software. The analysis of gender, age, major symptoms, tongue coating and pulse manifestation, distributions of syndrome types, frequency of medicines, medicine association degree and correlation between syndrome types and medicines of case data based on data mining was performed by Ancient and Modern Medical Cases Cloud Platform and SPSSAU. Results: According to statistics, the symptoms with the highest frequency were dyspnea, cough, expectoration and fatigue in order of frequency, with percentages exceeding 60% ; the tongue body was mostly light red, dark red and red, the tongue coating was mostly white and thin coating as well as white and thick coating, accounting for 37.46% , and the proportion of thick tongue coating was 55.69% ; the most common pulse manifestation was deep and thready pulse, accounting for 12.30% ; the main syndrome types were phlegm-heat obstructing the lung,phlegm turbidity obstructing the lung,dual deficiency of qi and yin in lung and kidney,phlegm- stasis obstructing the lung,and dual deficiency of the lung- spleen, followed by the syndrome types including exterior cold with interior fluid retention, lung- kidney qi deficiency, and lung yang deficiency. Among 215 Chinese herbal medicines in the 1 602 cases,the top 20 medicines in the list were Pheretima,Poria,Rhizoma Atractylodis Macrocephalae, Herba Ephedrae, Radix et Rhizoma Glycyrrhizae Praeparata cum Melle, Radix Astragali, Semen Sinapis, Rhizoma Belamcandae, Bombyx Batryticatus, Pericarpium Trichosanthis, Radix Saposhnikoviae, Semen Armeniacae Amarum, Radix Scutellariae, Folium Perillae, Radix Ophiopogonis, Radix Pseudostellariae, Cortex Magnoliae Officinalis, Radix et Rhizoma Glycyrrhizae, Rhizoma Pinelliae and Fructus Psoraleae. There were 20 pairs of medicine combinations whose support degree was set above 0.3 and confidence degree was set above 0.7 in high- frequency medicine association analysis. The top five medicine combinations were Rhizoma Atractylodis Macrocephalae-Poria,Bombyx Batryticatus-Pheretima,Semen Sinapis- Pheretima, Radix Pseudostellariae- Radix Astragali, and Semen Armeniacae Amarum- Herba Ephedrae. The correlation analysis of syndrome types and medicines showed that when the confidence level was above 0.5,a total of nine syndrome types were obtained,namely exterior cold with interior fluid retention, phlegm- stasis obstructing the lung, phlegm- heat obstructing the lung, lung qi deficiency, dual deficiency of the lung- spleen, lung- kidney qi deficiency, dual deficiency of qi and yin in lung and kidney, lung yang deficiency, and phlegm turbidity obstructing the lung, as well as nine types of core prescriptions. Conclusion:FENG Yi believes that the main etiology and pathogenesis of chronic obstructive pulmonary disease are qi deficiency,yang deficiency and external contraction with wind,etc.;the main pathological products are phlegm and blood stasis; the treatment is mainly to warm yang and boost qi, supplemented by scattering wind and diffusing the lung,as well as directing qi downward and dissolving phlegm, and at the same time products are applied to invigorate blood and dissolve stasis based on different syndromes.