Abstract： Through the description of the characteristics of collateral vessels in the eye and the physiological and pathological characteristics of the true qi and qi collaterals in the eye，this paper explores the relationship between collateral vessels lesions and chronic central serous chorioretinopathy(CSC). And it is believed that CSC is closely related to collateral vessels-qi collaterals. The main pathogenesis of CSC is the depletion of healthy qi，disharmony of qi collaterals and qi stagnation and water retention；disharmony of qi collaterals and constraint of collateral vessels may lead to a prolonged duration of CSC；depletion of the spleen and kidney，lack of collateral qi，and weak qi collaterals easily lead to recurrence of CSC. In the acute stage， Chaigui tang， Chailing tang and Chaihu Sanren tang can be used based on syndrome differentiation to resolve constraint and harmonize collaterals，and promote urination and dispel dampness. In the prolonged stage， Linggui Zhugan tang and Zhenwu tang can be used based on syndrome differentiation to prevent collateral accumulation， and also can be modified with seed kernel herbs to supplement and boost the liver and kidney，and invigorate blood and improve vision. After healing，special attention should be paid to the protection of the spleen and stomach and the adjustment of emotion.