Abstract： Objective： To observe the effect of moxibustion combined with cognitive rehabilitation training on cognitive function and activities of daily living of patients with cerebral apoplexy. Methods： A total of 80 cases of patients with cerebral apoplexy were selected and divided into the observation group and the control group according to the random number table method， with 40 cases in each group. The control group was given routine rehabilitation training， and the observation group was additionally given moxibustion combined with cognitive rehabilitation training based on the treatment of the control group. The clinical effects in the two groups were compared. The changes in scores of Chinese medicine syndromes， Fugl- meger Motor Function Assessment(FMA)， National Institutes of Health Stroke Scale(NIHSS) and Activities of Daily Living(ADL) as well as values of serum indexes including S- 100β protein， fibroblast growth factor-23(FGF-23) and Klotho protein before and after treatment in the two groups were compared. Results：After treatment，the total effective rate of clinical effect was 87.50% in the observation group and 65.00% in the control group，the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the Chinese medicine syndrome score in the observation group was lower than that in the control group， differences being significant(P＜0.05). After treatment，the scores of all items in FMA and the total scores in the two groups were increased when compared with those before treatment，and the above scores in the observation group were higher than those in the control group，differences being significant(P＜0.05). After treatment， NIHSS scores in the two groups were decreased when compared with those before treatment， and ADL scores were increased， differences being significant(P＜0.05)； the NIHSS score in the observation group was lower than that in the control group，and the ADL score was higher，differences being significant(P＜0.05). After treatment，the levels of S- 100β，FGF- 23 and Klotho in the two groups were decreased when compared with those before treatment，and the values of the above three indexes in the observation group were lower than those in the control group，differences being significant(P＜0.05). Conclusion： The therapy of moxibustion combined with cognitive rehabilitation training for patients with cerebral apoplexy can improve their cognitive function and activities of daily living， and promote rehabilitation.