Abstract： Objective： To observe the clinical effect of ultramicro needle- knife combined with Yicupping therapy for shoulder joint pain in stroke. Methods： A total of 85 cases of stroke patients with shoulder joint pain were divided into the control group(42 cases) and the observation group(43 cases) according to their treatment. Both groups were given routine treatment methods for cerebrovascular disease； the control group was additionally treated with acupuncture， and the observation group was additionally treated with ultramicro needle- knife combined with Yi- cupping therapy. Both groups were treated for two courses，a total of 4 weeks. Before treatment and after four-week treatment，the scores of Fugl- Meyer Assessment， Visual Analogue Scale(VAS)， Modified Barthel Index(MBI)， and shoulder range of motion in the two groups were evaluated. The clinical effects in the two groups were compared. Results：After four-week treatment，the total effective rate of clinical effect in the observation group was higher than that in the control group(P＜0.05). The scores of Fugl- Meyer， MBI and shoulder range of motion in the two groups were increased when compared with those before treatment， and the VAS scores were decreased， differences being significant(P＜0.01)； the scores of Fugl- Meyer， MBI and shoulder range of motion in the observation group were higher than those in the control group，and the VAS score was lower， differences being significant(P＜0.01). Conclusion： Ultramicro needle- knife combined with Yi-cupping therapy has a definite curative effect for stroke patients with shoulder joint pain，which can effectively relieve shoulder joint pain，and improve shoulder range of motion，motor function and activities of daily living.