Abstract： Objective： To observe the clinical effect of Mingmu Dihuang tang combined with triamcinolone acetonide for senile cataract. Methods： A total of 72 cases of patients with senile cataract were selected and randomly divided into the control group and the study group， with 36 cases in each group. The control group was treated with triamcinolone acetonide based on routine symptomatic treatment，and the study group was additionally treated with Mingmu Dihuang tang based on the treatment of the control group. Both groups were treated for three months. The changes in visual acuity，the levels of inflammatory factors including interleukin- 6(IL-6)， tumor necrosis factor- α(TNF- α) and high-sensitivity C- reactive protein(hs- CRP)， and oxidative stress indexes including malondialdehyde(MDA)， superoxide dismutase(SOD) and lipid peroxidation(LPO) before and after treatment as well as the total effective rates in the two groups were observed and compared. Results： After treatment， the total effective rate was 94.44% in the study group and 83.33% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of visual acuity between the two groups(P＞0.05). After one， two and three months of treatment， the levels of visual acuity in the two groups were increased when compared with those before treatment(P＜0.05)，and the level of visual acuity in the study group was significantly higher than that in the control group at the same treatment time point(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of IL- 6，TNF- α and hs- CRP in serum between the two groups(P＞0.05). After treatment， the levels of IL- 6， TNF- α and hs- CRP in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above indexes in the study group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of MDA，SOD and LPO between the two groups(P＞0.05). After treatment， SOD levels in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of MDA and LPO were decreased(P＜0.05)；the improvement of the above indexes in the study group was more significant than that in the control group(P＜0.05). Conclusion： The therapy of Mingmu Dihuang tang combined with triamcinolone acetonide has a significant curative effect，and can effectively improve the visual acuity of patients with senile cataract， reduce the levels of inflammatory factors and enhance the ability of anti-oxidation.