Abstract： Objective： To observe the clinical effect of Bushen Huoxue paste for premature ovarian insufficiency(POI) of the kidney deficiency and blood stasis type and its effects on sexual satisfaction scores. Methods： The POI patients were divided into four groups， with 30 cases in each group. The western medicine group was treated with fenmotone； the Chinese medicine group was treated with the hospital prescription， namely Bushen Huoxue paste； the integrated Chinese and western medicine group was treated with fenmotone and Bushen Huoxue paste；30 cases of POI patients who refused any treatment were enrolled in the control group. The levels of serum follicle stimulating hormone(FSH)， luteinizing hormone(LH) and anti mullerian hormone(AMH)， body mass index(BMI)， Chinese medicine syndrome scores and sexual satisfaction scores of all patients before and after treatment were observed and compared. Results：Finally，there were 27 cases in the western medicine group，28 cases in the Chinese medicine group， 25 cases in the integrated Chinese and western medicine group， and 30 cases in the control group. The comparison of the total effective rates and the cure rates among the western medicine group， the Chinese medicine group， and the integrated Chinese and western medicine group showed significance in differences(P＜0.05)， and the two rates in the integrated Chinese and western medicine group were better than those in the western medicine group and the Chinese medicine group. There was no significant difference being found in the comparison of BMI before and after treatment in the four groups(P＞ 0.05)；there was no significant difference being found in the comparison of BMI among the four groups(P＞ 0.05). After treatment， Chinese medicine syndrome scores in the Chinese medicine group and the integrated Chinese and western medicine group were decreased when compared with those before treatment，differences being significant(P＜0.05). The scores from low to high were the integrated Chinese and western medicine group，the Chinese medicine group，and the western medicine group，differences being significant(P＜0.05). After treatment，the sexual satisfaction scores in the western medicine group， the Chinese medicine group， and the integrated Chinese and western medicine group were increased when compared with those before treatment， differences being significant(P＜0.05)； the sexual satisfaction scores in the Chinese medicine group and the integrated Chinese and western medicine group were better than that in the western medicine group， differences being significant(P＜0.05). After treatment，FSH and LH in the western medicine group，the Chinese medicine group，and the integrated Chinese and western medicine group were decreased when compared with those before treatment， differences being significant(P＜0.05). After treatment， AMH in the integrated Chinese and western medicine group and the Chinese medicine group were increased when compared with that before treatment， the difference being significant(P＜0.05). The AMH in the integrated Chinese and western medicine group was higher than those in the other three groups， differences being significant(P＜0.05). Conclusion：Bushen Huoxue paste can significantly improve the sex hormones levels of patients with POI， relieve clinical symptoms and enhance sexual satisfaction rate.