Abstract：Objective：To observe the clinical effect of Shangxia Liangji pills combined with transcranial magnetic stimulation for chronic insomnia in senile patients of heart-kidney non-interaction type. Methods： A total of 94 cases of senile patients with chronic insomnia of heart- kidney non- interaction type were divided into the control group and the observation group according to the random number table method， with 47 cases in each group. The control group was treated with transcranial magnetic stimulation，and the observation group was treated with Shangxia Liangji pills combined with transcranial magnetic stimulation. Both groups were treated for four weeks. The clinical effects and the incidence of adverse reactions in the two groups were compared； the changes in sleep quality and levels of S100B and neuron-specific enolase (NSE) in serum before and after treatment in the two groups were observed. Results：The total effective rate was 93.62% in the observation group，higher than that of 76.60% in the control group(P＜0.05). After treatment， the total sleep time in the two groups were prolonged when compared with those before treatment(P＜0.05)， the number of awakening were reduced(P＜0.05)， and the Insomnia Severity Index (ISI) scores were decreased(P＜0.05)； the total sleep time in the observation group was longer than that in the control group(P＜0.05)， the number of awakening was fewer(P＜0.05)， and the ISI score was lower (P＜0.05). After treatment，the levels of S100B and NSE in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of S100B and NSE in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 10.64% in the observation group and 6.38% in the control group，there being no significance in the difference(P＞0.05). Conclusion：Shangxia Liangji pills combined with transcranial magnetic stimulation for senile patients with chronic insomnia of heart-kidney non-interaction type can enhance the curative effect，improve the sleep quality and reduce the levels of S100B and NSE in serum，with good safety.