Abstract：Objective：To observe the clinical effect of Zhibai Dihuang pills in the adjuvant treatment of diabetic nephropathy. Methods：A total of 196 cases of patients with diabetic nephropathy were selected and divided into the control group and the observation group according to the random number table method， with 98 cases in each group. Both groups were treated with routine western medicine； the control group was treated with captopril and metformin hydrochloride tablets， and the observation group was additionally treated with Zhibai Dihuang pills based on the treatment of the control group. The adverse reactions during treatment and the clinical effects in the two groups were observed. The changes in levels of blood glucose indexes including fasting blood glucose(FBG)，two-hour postprandial blood glucose(P2hBG) and glycosylated hemoglobin(HbA1c)，blood lipid indexes including triglyceride(TG)，total cholesterol(TC)， low- density lipoprotein- cholesterol(LDL- C) and high- density lipoprotein- cholesterol(HDL- C) as well as kidney function indexes including serum creatinine(SCr) and urea nitrogen(BUN) before and after treatment in the two groups were detected. Results： The total effective rate was 94.90% in the observation group and 81.63% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of blood glucose indexes including FBG， P2hBG and HbA1c between the two groups(P＞0.05). After treatment， the levels of FBG， P2hBG and HbA1c in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of FBG，P2hBG and HbA1c in the observation group were lower than those in the control group(P＜ 0.05). Before treatment，there was no significant difference being found in the comparison of the levels of TG，TC，LDL-C and HDL-C between the two groups(P＞0.05). After treatment，the levels of TG，TC and LDL-C in the two groups were decreased when compared with those before treatment，and the levels of HDL- C were increased(P＜0.05). The improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of kidney function indexes including SCr and BUN between the two groups(P＞0.05). After treatment， the levels of SCr and BUN in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of SCr and BUN in the observation group were lower than those in the control group(P＜0.05). During treatment，the incidence of adverse reactions was 20.41% in the observation group and 18.37% in the control group，there being no significant difference between the two groups(P＞0.05). Conclusion：Based on routine western medicine， the application of Zhibai Dihuang pills for diabetic nephropathy can help to improve the levels of blood glucose and blood lipid and kidney function in a short term，as well as enhance the clinical effect，without a significant increase in adverse reactions.