Abstract： Objective： To observe the curative effect of Danshao tang combined with cimetidine injection for Henoch- Schtinlein purpura(HSP) of cutaneous type in children and its effect on immune function. Methods：A total of 68 cases of children with HSP of cutaneous type were selected and divided into the control group and the treatment group according to the random number table method ， with 34 cases in each group. After admission， both groups were given routine basic treatment； the control group was treated with cimetidine injection，and the treatment group was additionally treated with Danshao tang based on the treatment of the control group. Both groups were treated for two courses，with 10 days being a course. The clinical effects in the two groups were compared； the changes of Chinese medicine syndrome scores and immune function indexes including CD3 + ， CD4 + and CD4 +/CD8 + before and after treatment in the two groups were compared；the remission time of clinical symptoms after treatment in the two groups was observed. Results：After treatment，the total effective rate of clinical effect was 94.12% in the treatment group and 76.47% in the control group， the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment， and the score in the treatment group was lower than that in the control group， differences being significant(P＜0.05). After treatment，the disappearance time of rash，pruritus and skin pain in the treatment group was shorter than that in the control group， differences being significant(P＜ 0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment， and the levels of CD8 + were decreased， differences being significant(P＜0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the treatment group were higher than those in the control group，and CD8 + level was lower，differences being significant(P＜0.05). Conclusion： The clinical application of cimetidine injection combined with Danshao tang for children with HSP of cutaneous type can improve the clinical effect，promote the improvement of symptoms and signs in children and enhance their body immunity.