Abstract： Objective： To observe the clinical effect of Yishen Huatan prescription combined with acupuncture for infertility due to polycystic ovary syndrome of the kidney deficiency with phlegm-dampness type. Methods： A total of 90 cases of patients with infertility due to polycystic ovary syndrome were selected and divided into the acupuncture- medication group， the Chinese medicine group， and the acupuncture group according to the random number table method， with 30 cases in each group. The Chinese medicine group was treated with Yishen Huatan prescription，the acupuncture group was treated with acupuncture， and the acupuncture- medication group was treated with Yishen Huatan prescription combined with acupuncture. The changes of basal body temperature(BBT) and B- mode ultrasound before and after treatment were compared among the three groups；the levels of sex hormones and ovulation rate were detected，and clinical effects were evaluated. Results：Before treatment，there was no significant difference being found in the comparison of BBT dynamic curve typing among the three groups(P＞0.05). After treatment for three menstrual periods，the BBT dynamic curve typing in the three groups changed to type I and II， but the change in the acupuncture- medication group was more obvious(P＜0.05). Before treatment，there was no significant difference being found in the comparison of maximum follicle diameter and endometrial thickness among the three groups(P＞0.05). After treatment， maximum follicle diameter and endometrial thickness in the three groups were increased when compared with those before treatment， and the maximum follicle diameter and endometrial thickness in the acupuncture- medication group were larger than those in the other two groups(P＜0.05). Before treatment，there was no significant difference being found in the comparison of E2，T，FSH，and LH among the three groups(P＞0.05). After treatment， E2 in the acupuncture- medication group was increased when compared with that before treatment，and T，FSH，and LH were decreased(P＜0.05)；the level of T in the acupuncture-medication group was lower than those in the Chinese medicine group and the acupuncture group(P＜0.05). After treatment， the ovulation rate was 83.33% in the acupuncture- medication group， higher than that of 50.00% in the Chinese medicine group and that of 46.67% in the acupuncture-medication group(P＜0.05). Conclusion： Yishen Huatan prescription combined with acupuncture for infertility due to polycystic ovary syndrome of the kidney deficiency with phlegm- dampness type can regulate hormone levels and endometrial thickness，improve menstrual period，and promote ovulation.