Abstract： Objective： To observe the clinical effect of Bushen Antai tang combined with point application assisting western medicine for restless fetus(threatened abortion) of the spleen- kidney deficiency type and their effects on human chorionic gonadotropin β(β- HCG)， progesterone(P)， and estradiol(E2) in serum. Methods： A total of 97 cases of patients with restless fetus of the spleen- kidney deficiency type were selected and divided into the Chinese and western medicine group and the western medicine group according to the random number table method， with 49 and 48 cases in each group respectively. The western medicine group was given progesterone and human chorionic gonadotropin(HCG) intramuscularly，and the Chinese and western medicine group was additionally treated with Bushen Antai tang combined with point application based on the treatment of the western medicine group. The clinical effects and changes of related indexes were compared between the two groups. Results： The total effective rate was 95.92% in the Chinese and western medicine group，higher than that of 81.25% in the western medicine group(P＜0.05). After treatment， Chinese medicine syndrome scores， uterine blood flow resistance index(RI)， arterial pulsatility index(PI) and levels of interleukin- 2(IL- 2) and γ- Interferon (INF- γ) in serum in the two groups were decreased when compared with those before treatment(P＜ 0.05)， and levels of E2， P， β- HCG， interleukin- 4(IL- 4)， and interleukin- 10(IL- 10) in serum were increased(P＜0.05). After treatment，Chinese medicine syndrome score，uterus RI，PI and levels of IL-2 and INF- γ in serum in the Chinese and western medicine group were lower than those in the western medicine group(P＜0.05)，and level of E2，P，β-HCG，IL-4，and IL-10 in serum were higher(P＜0.05). Conclusion： For patients with restless fetus(threatened abortion) of the spleen- kidney deficiency type， Bushen Antai tang combined with point application assisting western medicine can significantly improve their clinical symptoms and uterine hemodynamic indexes，effectively regulate the levels of sex hormones and inflammatory cytokines in serum， and has a significant clinical effect， which is conducive to maintaining pregnancy.